Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/28042
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Felice, Alex | - |
dc.contributor.author | Cleek, M. P. | - |
dc.contributor.author | Marino, E. M. | - |
dc.contributor.author | McKie, Kathleen Mood | - |
dc.contributor.author | McKie, Virgil C. | - |
dc.contributor.author | Chang, B. K. | - |
dc.contributor.author | Huisman, Titus Hendrik Jan | - |
dc.date.accessioned | 2018-03-16T13:45:56Z | - |
dc.date.available | 2018-03-16T13:45:56Z | - |
dc.date.issued | 1986 | - |
dc.identifier.citation | Felice, A. E., Cleek, M. P., Marino, E. M., McKie, K. M., McKie, V. C., Chang, B. K., & Huisman, T. H. J. (1986). Different ζ globin gene deletions among Black Americans. Human Genetics, 73(3), 221-224. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/28042 | - |
dc.description.abstract | Four types of chromosomes with a deletion between the human embryonic ζ and ψζ globin genes were identified among 2.8% of 321 Black Americans from Georgia. Two deletions of approximately 11 kb which differed by about 300 bp occurred on chromosomes with or without a polymorphic Xba I site 5′ to the ζ globin gene [(X+) or (X-)]. The deletions are identifiable in Xba I digests of genomic DNA using an α or a ζ globin gene probe which yield fragments of 23 kb from (X+)-ζ*αα chromosomes or 27 kb from (X-)-ζ*αα chromosomes. Digestion with other enzymes and probing with both α and ζ probes gave fragments typical of the two ζ globin gene deletions previously identified in Polynesians. Among Black Americans, these ζ globin gene deletions have been found in combination with α globin gene deletions in trans but not in cis. Homozygotes have not been found. Hematologic data on carriers of the ζ globin gene deletions in association with Hb AS, SS, and SC suggest that these deletions have no effect on the function of the adult α globin genes. | en_GB |
dc.description.sponsorship | This research was supported by designated research funds of the Veterans Administration and by USPHS research grant HLB-15158. This is contribution number 874 of the Department of Cell and Molecular Biology of the Medical College of Georgia, Augusta, Ga. Some of these data were presented at the 5th Cooley's Anemia Symposium, New York Academy of Sciences, New York, N.Y., June 1984. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Sickle cell anemia | en_GB |
dc.subject | Hemoglobin polymorphisims | en_GB |
dc.title | Different ζ globin gene deletions among Black Americans | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1007/BF00401231 | - |
dc.publication.title | Human Genetics | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Different_ζ_globin_gene_deletions_among_Black_Americans_1986.pdf Restricted Access | 395.16 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.