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DC Field | Value | Language |
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dc.contributor.author | Abou-Hussein, S. | - |
dc.contributor.author | Savona-Ventura, Charles | - |
dc.contributor.author | Grima, Stephen | - |
dc.contributor.author | Felice, Alex | - |
dc.date.accessioned | 2018-03-16T14:00:44Z | - |
dc.date.available | 2018-03-16T14:00:44Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Abou-Hussein, S., Savona-Ventura, C., Grima, S., & Felice, A. (2011). Genetic factors in risk assessment for the development of type 2 diabetes mellitus in a small case series. International Journal of Risk & Safety in Medicine, 23(2), 119-123. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/28043 | - |
dc.description.abstract | Abstract. Objective: This study aimed to investigate the role of genetic biomarkers in assessing risk for the eventual development of type 2 diabetes mellitus (T2DM). Methods: Three Maltese women with a history of previous severe GDM and with apparent similar clinical risk factors underwent anthropomorphic and metabolic reassessment 4–7 years post-partum. They were further genotyped for four specific genetic single nucleotide polymorphisms (SNPs) using the qPCR technique for the alleles of SLC2A2 (rs5393A/C), FTO (rs9939609A/T), PCK (rs2071023C/G) and CDKAL1 (rs10946398A/C). Results: While the previous obstetric history of all the caseswas similar, the biological statuswas characterized by an increasing degree of obesity correlating to increasing severity of current carbohydrate intolerance. Genotyping showed that all the tested SNPs were homozygous mutant in the T2DM woman and heterozygous in the impaired glucose tolerance woman. The woman with normal glucose tolerance was shown to be wild type for SLC2A2 (rs5393A/C). Conclusions: There appeared to be an interrelationship between eventual severity of carbohydrate metabolism abnormalities and the genetic allele status. It would appear that the specific allele-scoring can be used to identify further the potential risk of developing T2DM. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | BMJ | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Diabetes -- Genetic aspects | en_GB |
dc.subject | Diabetes -- Risk factors | en_GB |
dc.subject | Diabetes -- Malta | en_GB |
dc.title | Genetic factors in risk assessment for the development of type 2 diabetes mellitus in a small case series | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3233/JRS-2011-0522 | - |
dc.publication.title | International Journal of Risk & Safety in Medicine | en_GB |
Appears in Collections: | Scholarly Works - FacM&SOG Scholarly Works - FacM&SPB |
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