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DC Field | Value | Language |
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dc.contributor.author | Orringer, Eugene P. | - |
dc.contributor.author | Felice, Alex | - |
dc.contributor.author | Reese, A. L. | - |
dc.contributor.author | Wilson, Jerry B. | - |
dc.contributor.author | Lam, H. L. | - |
dc.contributor.author | Gravely, Marsha E. | - |
dc.contributor.author | Huisman, Titus Hendrik Jan | - |
dc.date.accessioned | 2018-03-16T14:35:08Z | - |
dc.date.available | 2018-03-16T14:35:08Z | - |
dc.date.issued | 1978 | - |
dc.identifier.citation | Orringer, E. P., Felice, A., Reese, A., Wilson, J. B., Lam, H., Gravely, M. E., & Huisman, T. H. J. (1978). Hb Nottingham (α; 2β; 2 (FG5) 98 VAL→ GLY) in a caucasian male: Clinical and biosynthetic studies. Hemoglobin, 2(4), 315-332. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/28051 | - |
dc.description.abstract | A second instance of the unstable mutant Hb Nottingham (α;2β;2 (FG5) 98 Val→Gly) is reported in a 7-year-old boy. Because of splenomegaly, cholelithiasis, and frequent episodes of abdominal pain, he underwent a splenectomy and cholecystectomy at age 6. The surgery resulted in both an amelioration of his RBC destruction and an acceleration of his rate of growth. Biosynthetic studies were carried out using reticulocytes obtained from his peripheral blood. These analyses disclosed an exceedingly high specific activity ratio for Hb N/Hb A. In addition as the incubation proceeded, more radioactivity accumulated in the α; chain fraction than in the β; chains (β;A+beta;;N). This observation is presumed secondary to degradation of the unstable β;N chains. | en_GB |
dc.description.sponsorship | This work was supported in part by the United States Public Health Service Research Grants AM1 1356, HLB-05168 and HLB- 15158. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Taylor & Francis | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Hemoglobin polymorphism | en_GB |
dc.subject | Hemoglobins, Abnormal | en_GB |
dc.subject | Splenectomy | en_GB |
dc.title | Hb Nottingham (α;2β;2 (FG5) 98 VAL→GLY) in a Caucasian male : clinical and biosynthetic studies | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3109/03630267809005343 | - |
dc.publication.title | Hemoglobin | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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