Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/28244
Title: Role of receptor protein tyrosine phosphatase α (RPTPα) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels
Authors: Imbrici, Paola
Tucker, Stephen J.
D'Adamo, Maria Cristina
Pessia, Mauro
Keywords: Potassium channels
Phosphorylation
Phosphatases
Tyrosine
Issue Date: 2000
Publisher: Springer
Citation: Imbrici, P., Tucker, S. J., D'Adamo, M. C., & Pessia, M. (2000). Role of receptor protein tyrosine phosphatase α (RPTPα) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels. Pflugers Archiv European Journal of Physiology, 441(2-3), 257-262.
Abstract: The activity of voltage-gated potassium (Kv) channels can be dynamically modulated by several events, including neurotransmitter-stimulated biochemical cascades mediated by G-protein-coupled receptors. By using a heterologous expression system, we show that activating the 5-HT2C receptor inhibits both Kv1.1 and Kv1.2 channels through a tyrosine phosphorylation mechanism. The major molecular determinants of channel inhibition were identified as two tyrosine residues located in the N-terminal region of the Kv channel subunit. Furthermore, we demonstrate that receptor protein tyrosine phosphatase α (RPTPα), a receptor protein tyrosine phosphatase, co-ordinates the inhibition process mediated via 5-HT2C receptors. We therefore propose that the serotonergic regulation of human Kv1.1 and Kv1.2 channel activity by the 5-HT2C receptor involves the dual coordination of both RPTPα and specific tyrosine kinases coupled to this receptor.
URI: https://www.um.edu.mt/library/oar//handle/123456789/28244
Appears in Collections:Scholarly Works - FacM&SPB

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