Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/28678
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAgius, Rachel-
dc.contributor.authorGalea, Raymond P.-
dc.contributor.authorFava, Stephen-
dc.date.accessioned2018-04-04T08:43:58Z-
dc.date.available2018-04-04T08:43:58Z-
dc.date.issued2016-
dc.identifier.citationAgius, R., Galea, R., & Fava, S. (2016). Bone mineral density and intervertebral disc height in type 2 diabetes. Journal of diabetes and its complications, 30(4), 644-650.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/28678-
dc.description.abstractBackground Studies of the effect of type 2 diabetes (T2D) on bone mineral density (BMD have produced conflicting results, possibly due to failure to adjust for potential confounding factors. Nonetheless, T2D has consistently been associated with increased fracture risk, suggesting that other factors might play a role. Objective This study assesses the relationship between T2D and BMD at the femoral neck and spine in diabetic and non-diabetic subjects, after adjusting for multiple covariates which may affect BMD. Intervertebral disc height was also investigated in view of its possible relation to fracture risk. Methods A cross-sectional study of 100 patients with T2DM of at least 5 years duration and 86 non-diabetic subjects was carried out. Results There were no significant differences in T scores in either the spine or femoral neck after adjustment for potential confounding variables between T2D subjects and controls. Diabetic patients had a statistically lower intervertebral disc height between the 2nd and 3rd lumbar vertebrae (D3) after adjustment for potential confounders (p = 0.004). Urinary albumin:creatinine ratio, total cholesterol, LDL-cholesterol and cigarette smoking were independently associated with lower height of D3 in diabetic subjects. Conclusions There is no significant independent association between T2D and BMD. However we found a novel association of significantly lower disc height in patients with T2D. This may contribute to the increased vertebral fracture risk in subjects with T2D. Further studies are needed to investigate the relationship of disc height, T2D and fracture risk.en_GB
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectOsteoporosis -- Malta -- Case studiesen_GB
dc.subjectBone densityen_GB
dc.subjectIntervertebral disc degenerationen_GB
dc.subjectDiabetes Mellitus, Type 2en_GB
dc.titleBone mineral density and intervertebral disc height in type 2 diabetesen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1016/j.jdiacomp.2016.01.021-
dc.publication.titleJournal of Diabetes and its Complicationsen_GB
Appears in Collections:Scholarly Works - FacM&SMed
Scholarly Works - FacM&SOG

Files in This Item:
File Description SizeFormat 
Bone_mineral_density_and_intervertebral_disc_height_in_type_2_diabetes_2016.pdf
  Restricted Access
383.22 kBAdobe PDFView/Open Request a copy


Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.