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dc.contributor.authorFava, Stephen-
dc.contributor.authorAzzopardi, Joseph-
dc.contributor.authorHattersley, Andrew T.-
dc.contributor.authorWatkins, Peter J.-
dc.date.accessioned2018-04-04T09:30:47Z-
dc.date.available2018-04-04T09:30:47Z-
dc.date.issued2000-
dc.identifier.citationFava, S., Azzopardi, J., Hattersley, A. T., & Watkins, P. J. (2000). Increased prevalence of proteinuria in diabetic sibs of proteinuric type 2 diabetic subjects. American Journal of Kidney Diseases, 35(4), 708-712.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/28695-
dc.description.abstractThere is strong evidence for clustering of renal disease in type 1 diabetes, but few data exist with respect to type 2 diabetes. The objective of this case-control study is to determine whether there is a familial predisposition to the development of proteinuria in patients with type 2 diabetes. Fifty patients with type 2 diabetes with macroproteinuria (protein ≥ 500 mg/24 h) with no evidence of causes other than diabetic nephropathy on investigation were identified through routine screening. These patients had 25 living sibs with diabetes, of whom 24 sibs agreed to participate on the study. For each of these sibs, two controls with non-insulin-dependent diabetes were randomly selected, individually matched for age, sex, and duration of diabetes. Twelve of 24 sibs (50%) and 9 of 48 controls (18.8%) had proteinuria (P < 0.01). Systolic and diastolic blood pressure and the proportion on antihypertensive treatment were similar in the two groups. Our data suggest there is increased prevalence of macroproteinuria in diabetic sibs of macroproteinuria patients with type 2 diabetes in a population of white, Caucasian, European descent.en_GB
dc.language.isoenen_GB
dc.publisherNational Kidney Foundationen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectProteinuriaen_GB
dc.subjectDiabetes Mellitus, Type 2en_GB
dc.subjectDiabetic nephropathies -- Maltaen_GB
dc.titleIncreased prevalence of proteinuria in diabetic sibs of proteinuric type 2 diabetic subjectsen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1016/S0272-6386(00)70019-9-
dc.publication.titleAmerican Journal of Kidney Diseasesen_GB
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