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DC Field | Value | Language |
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dc.contributor.author | Magri, Caroline Jane | - |
dc.contributor.author | Cassar, Andrew | - |
dc.contributor.author | Fava, Stephen | - |
dc.contributor.author | Felice, Herbert | - |
dc.date.accessioned | 2018-04-04T10:01:23Z | - |
dc.date.available | 2018-04-04T10:01:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Magri, C. J., Cassar, A., Fava, S., & Felice, H. (2012). Heart failure with preserved ejection fraction and diabetes mellitus. Journal of Diabetes Research and Clinical Metabolism, 1(1), 1-10. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/28702 | - |
dc.description.abstract | Heart failure with preserved ejection fraction (HFpEF) constitutes approximately 50% of heart failure patients. The prevalence of diabetes mellitus in HFpEF is high at 30-40%. The paper provides a systematic review of the pathophysiological features underlying HFpEF in diabetes mellitus. The importance of mechanisms other than left ventricular diastolic dysfunction underlying this important condition is emphasised. Thus, ventricular-arterial coupling & vascular dysfunction together with chronotropic incompetence & cardiovascular reserve dysfunction play an important role. The various morphologic and molecular features occurring in the myocardium and vasculature in diabetes secondary to hyperglycaemia and other metabolic disturbances are also discussed. These include microangiopathy, myocardial fibrosis, increased oxidative stress, impaired calcium homeostasis, activation of the cardiac renin-angiotensin system, autonomic neuropathy, endothelial dysfunction, re-expression of foetal gene response as well as stem cell involvement. Nonetheless, a lot is still unknown and further studies are needed to establish the underlying pathophysiological mechanisms with the hope that novel pharmacotherapies targeting this disease will be developed. In the meantime, cardiometabolic factors, including hyperglycaemia, hypertension and dyslipidaemia should be targeted and aggressively treated. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Herbert Publications | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Heart failure | en_GB |
dc.subject | Diabetes | en_GB |
dc.title | Heart failure with preserved ejection fraction and diabetes mellitus | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.7243/2050-0866-1-2 | - |
dc.publication.title | Journal of Diabetes Research and Clinical Metabolism | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
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Heart_failure_with_preserved_ejection_fraction_and_diabetes mellitus_2012.pdf | 477.95 kB | Adobe PDF | View/Open |
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