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dc.contributor.authorDincol, G.
dc.contributor.authorAltay, C.
dc.contributor.authorAksoy, M.
dc.contributor.authorGurgey, Aytemiz
dc.contributor.authorFelice, Alex E.
dc.contributor.authorHuisman, Titus Hendrik Jan
dc.date.accessioned2018-04-06T12:18:19Z
dc.date.available2018-04-06T12:18:19Z
dc.date.issued1981
dc.identifier.citationDincol, G., Altay, C., Aksoy, M., Gurgey, A., Felice, A. E., & Huisman, T. H. J. (1981). Clinical and hematological evaluation of two delta 0 beta 0 - thalassemia homozygotes. Hemoglobin, 5(2), 153-164.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/28893
dc.description.abstractTwo homozygous δ0 β0-thalassemia patients, one with the GγAγ type and the other with the Gγ type, and their heterozygous parents are described. Red cell indices among the heterozygotes with the GγAγ type of δ0β0-thalassemia were markedly different from those in heterozygotes with the Gγ type. However, the imbalance in in vitro hemoglobin synthesis was quite similar in the two heterozygous conditions. The same was observed for the homozygous patients; the in vitro chain synthesis was severely imbalanced as seen in β-thalassemia major. The clinical and some of the hematological findings were milder in the Gγ-δ0 β0-thalassemia homozygote than in the GγAγ - δ0 β0-thalassemia homozygote. The death of a sibling of the Gγ - δ0 β0-thalassemia homozygote with a diagnosis of thalassemia major suggests that both types of δ0 β0 -thalassemia could follow a severe clinical and hematological course. The discovery of the Gγ type of δ0 β0-thalassemia in a Turkish child shows that two types of δ0 β0 - thalassemia can be found in that country. Differentiation between the two types can only be made through structural analyses of Hb F.en_GB
dc.language.isoenen_GB
dc.publisherTaylor & Francisen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectHematologyen_GB
dc.subjectHomozygoteen_GB
dc.subjectThalassemia in children -- Turkeyen_GB
dc.titleClinical and hematological evaluation of two δ0 δ0 - thalassemia homozygotesen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.3109/03630268108996921
dc.publication.titleHemoglobinen_GB
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