Please use this identifier to cite or link to this item:
Title: Non-dipping heart rate and microalbuminuria in type 2 diabetes mellitus
Authors: Magri, Caroline Jane
Xuereb, Robert G.
Fava, Stephen
Keywords: Blood pressure
Cardiovascular system -- Diseases -- Risk factors
Diabetes Mellitus, Type 2
Issue Date: 2014
Publisher: Karger
Citation: Magri, C. J., Xuereb, R. G., & Fava, S. (2014). Non-dipping heart rate and microalbuminuria in type 2 diabetes mellitus. Cardiology, 129(1), 28-35.
Abstract: Objectives: The aim of this study was to identify factors which are independently associated with non-dipping heart rate (HR) in a type 2 diabetic population at high risk of cardiovascular disease. Methods: The study recruited 179 type 2 diabetic subjects with a mean diabetes duration of 18.3 years and with proliferative retinopathy. All underwent 24-hour blood pressure and HR monitoring, and were assessed for markers of inflammation, insulin resistance, albuminuria, presence of peripheral neuropathy and peripheral vascular disease. Subjects whose night-time HR did not decrease by more than 10% as compared to daytime readings were classified as non-dippers. Results: Univariate analysis revealed that non-dippers had significantly higher logarithmic albumin-creatinine ratio (ACR; p = 0.001) and higher platelet count (p = 0.014). Also, non-dippers were more likely to be on β-blockers (p = 0.037). Binary logistic regression analysis showed that logarithmic ACR (p = 0.001) and platelet count (p = 0.026) were independent predictors of non-dipping HR, even when correcting for β-blocker use. Conclusions: In this high-risk type 2 diabetic population, non-dipping HR was independently associated with ACR and platelet count, suggesting that non-dipping HR might give an indication of underlying generalised atherosclerosis in diabetic patients. Also, non-dipping HR may represent a novel mechanism explaining the association of nephropathy with cardiovascular events. This merits further study.
Description: Acknowledgements: The authors would like to like to thank all the staff at Diabetes Centre, Cardiac Laboratory, Biochemistry and Immunology Laboratory, Mater Dei Hospital, for their continuous help and support while carrying out this study.
Appears in Collections:Scholarly Works - FacM&SMed

Files in This Item:
File Description SizeFormat 
  Restricted Access
169.29 kBAdobe PDFView/Open Request a copy

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.