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DC Field | Value | Language |
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dc.date.accessioned | 2018-04-09T10:22:10Z | - |
dc.date.available | 2018-04-09T10:22:10Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | Eljali, S., Pace, N. P., Vassallo, J., & Felice, A. E. (2015). Molecular screening of the human melanocortin 4 receptor gene in obese Maltese type 2 diabetic patients. IX Malta Medical School Conference (2015). | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/28927 | - |
dc.description.abstract | Obesity is a complex trait that arises from the interaction between lifestyle and a number of genetic factors. It is a risk factor for cardio-metabolic diseases, including type 2 diabetes (T2DM). GWAS have identified associations between around 50 individual SNVs and non-syndromic obesity, as defined by the BMI, waist circumference and waist-hip ratio. The first gene shown to have unequivocal association with obesity was FTO. Subsequently, investigations into early onset/severe obesity have identified variants in genes acting on the central regulation of appetite. Of particular interest is the melanocortin 4 receptor (MC4R). This is the hypothalamic receptor for melanocyte stimulating hormone, and blockade of this signaling pathway leads to hyperphagia and reduced energy expenditure. A large number of studies have investigated the role of genetic variation in MC4R, and mutations in this gene represent the most frequent cause of early-onset non-syndromic obesity. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | University of Malta | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Molecular genetics | en_GB |
dc.subject | Diabetes -- Malta -- Case studies | en_GB |
dc.subject | Obesity -- Malta -- Case studies | en_GB |
dc.title | Molecular screening of the human melanocortin 4 receptor gene in obese Maltese type 2 diabetic patients | en_GB |
dc.type | conferenceObject | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.bibliographicCitation.conferencename | IX Malta Medical School Conference (2015) | en_GB |
dc.bibliographicCitation.conferenceplace | Malta, 3-5/12/2015 | en_GB |
dc.description.reviewed | N/A | en_GB |
dc.contributor.creator | Eljali, Seham | - |
dc.contributor.creator | Pace, Nikolai Paul | - |
dc.contributor.creator | Vassallo, Josanne | - |
dc.contributor.creator | Felice, Alex | - |
Appears in Collections: | Scholarly Works - FacM&SAna Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Molecular_screening_of_the_human_Melanocortin_4_receptor_gene_in_obese_Maltese_Type_2_2015.pdf | 589.51 kB | Adobe PDF | View/Open |
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