Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/29141| Title: | The Kir5.1 potassium channel is an important determinant of neuronal PCO2/pH sensitivity |
| Authors: | D'Adamo, Maria Cristina Shang, Lijun Imbrici, Paola Brown, Steve D. M. Pessia, Mauro Tucker, Stephen J. |
| Keywords: | Potassium channels |
| Issue Date: | 2011 |
| Publisher: | Elsevier |
| Citation: | D'Adamo, M. C., Shang, L., Imbrici, P., Brown, S. D., Pessia, M., & Tucker, S. J. (2011). The Kir5. 1 potassium channel is an important determinant of neuronal PCO2/pH sensitivity. Biophysical Journal, 100(3), 430a. |
| Abstract: | The molecular identity of ion channels which respond to PCO2/pH in the brain is still unclear. Heteromeric Kir4.1/Kir5.1 channels are highly sensitive to inhibition by intracellular pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory control, including the locus coeruleus (LC). This has therefore led to a proposed role for these channels in neuronal CO2-chemosensitivity. In order to examine this we generated mutant mice lacking the Kir5.1 (Kcnj16) gene. We show that whilst LC neurons from Kcnj16(+/+) mice rapidly respond to cytoplasmic alkalinization and acidification, those from Kcnj16(−/−) mice display a dramatically reduced and delayed response. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/29141 |
| Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| The_Kir5.1_potassium_channel_is_an_important_determinant_of_neuronal_PCO2pH sensitivity_2011.pdf Restricted Access | 57.18 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.