Please use this identifier to cite or link to this item:
|Title:||Pharmacogenetics of asthma|
|Authors:||Fenech, Anthony G.|
Hall, Ian P.
|Keywords:||Asthma -- Psychosomatic aspects|
|Publisher:||Wiley-Blackwell Publishing Ltd.|
|Citation:||Fenech, A., & Hall, I.P. (2002). Pharmacogenetics of asthma. British Journal of Clinical Pharmacology, 53(1), 3-15.|
|Abstract:||Recent advances in the extent of knowledge regarding interindividual genetic variation in drug treatment targets and drug metabolizing enzymes has resulted in studies designed to assess the contribution of genetic variability to treatment response in a range of diseases. This review describes the current state of knowledge of genetic variability in key airway targets important in the treatment of asthma. Whilst the genes coding for some key treatment targets contain little polymorphic variation (e.g. the muscarinic M2 and M3 receptors) other genes whose products are important targets in the treatment of asthma contain extensive genetic variation. The best examples of the latter are the β2-adrenoceptor and the 5-lipoxygenase genes. Genetic variability in both of these genes may account in part for interindividual variability in treatment response. Finally, a number of key targets within the airways remain to be adequately screened for polymorphic variation.|
|Appears in Collections:||Scholarly Works - FacM&SCPT|
Files in This Item:
|184.05 kB||Adobe PDF||View/Open Request a copy|
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.