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dc.contributor.authorFenech, Anthony G.
dc.contributor.authorHall, Ian P.
dc.identifier.citationFenech, A., & Hall, I.P. (2002). Pharmacogenetics of asthma. British Journal of Clinical Pharmacology, 53(1), 3-15.en_GB
dc.description.abstractRecent advances in the extent of knowledge regarding interindividual genetic variation in drug treatment targets and drug metabolizing enzymes has resulted in studies designed to assess the contribution of genetic variability to treatment response in a range of diseases. This review describes the current state of knowledge of genetic variability in key airway targets important in the treatment of asthma. Whilst the genes coding for some key treatment targets contain little polymorphic variation (e.g. the muscarinic M2 and M3 receptors) other genes whose products are important targets in the treatment of asthma contain extensive genetic variation. The best examples of the latter are the β2-adrenoceptor and the 5-lipoxygenase genes. Genetic variability in both of these genes may account in part for interindividual variability in treatment response. Finally, a number of key targets within the airways remain to be adequately screened for polymorphic variation.en_GB
dc.publisherWiley-Blackwell Publishing Ltd.en_GB
dc.subjectAsthma -- Psychosomatic aspectsen_GB
dc.subjectPolymorphism, Geneticen_GB
dc.subjectBeta adrenoceptorsen_GB
dc.titlePharmacogenetics of asthmaen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.publication.titleBritish Journal of Clinical Pharmacologyen_GB
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