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dc.contributor.authorCollict, Mandy-
dc.contributor.authorMuscat Baron, Yves-
dc.contributor.authorGatt, Miriam-
dc.contributor.authorCalleja, Neville-
dc.identifier.citationCollict, M., Muscat Baron, Y., Gatt, M., & Calleja, N. (2019). Maternal risks associated with pregnancy in women with advanced maternal age. Malta Medical Journal, 30(2), 5-13.en_GB
dc.description.abstractIntroduction: The trend towards delayed motherhood has accelerated in developed countries over the last few decades. Advanced maternal age (AMA) is defined as age 35 years and older at the estimated date of delivery. Objective: The aim of this large retrospective cohort study is to assess for the association between AMA and adverse maternal outcomes after adjustment for confounding factors in maternal characteristics and in the obstetric history. Study Design: Mothers of 20 years and older, who delivered singleton babies in Malta and Gozo between 1st January 2000 and 31st December 2014 were studied. All data was derived from the National Obstetric Information System. Results: The study population included 55,943 singleton births. 12.2% (6,838) of mothers were between 35 – 39 years and 2.4% (1,325) were 40 years and older. Significant difference was found between maternal age and BMI (p < 0.0001), maternal smoking status (p < 0.0001), non-insulin dependent diabetes mellitus (p = 0.004), history of stillbirth (p < 0.0001), gestational diabetes (p < 0.0001), pregnancy – induced – hypertension (p = 0.008) and pre-eclampsia (p = 0.008). Significant difference was also found between maternal age and mode of delivery (p < 0.0001). Regression analysis revealed persistent significant differences between maternal age and different maternal outcomes. Conclusion: This study demonstrates that AMA in Malta significantly increases the risk for hypertension in pregnancy, gestational diabetes and caesarean delivery. Care providers need to be aware of these increased risks and adjust their obstetric management according to the individual to ensure optimal maternal outcomes.en_GB
dc.publisherUniversity of Malta. Medical Schoolen_GB
dc.subjectPregnancy -- Complications -- Maltaen_GB
dc.subjectHypertension in pregnancy -- Maltaen_GB
dc.subjectDiabetes in pregnancy -- Maltaen_GB
dc.subjectPregnant women -- Maltaen_GB
dc.titleMaternal risks associated with pregnancy in women with advanced maternal ageen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleMalta Medical Journalen_GB
Appears in Collections:MMJ, Volume 30, Issue 2
MMJ, Volume 30, Issue 2

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