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DC Field | Value | Language |
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dc.date.accessioned | 2015-07-15T05:24:59Z | |
dc.date.available | 2015-07-15T05:24:59Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Balkan Journal of Medical Genetics. 2007, p. 9-18. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/4063 | |
dc.description.abstract | Two common single nucleotide polymorphisms (SNPs) within the COL1A1 gene and the C677T variant within the methylenetetrahydrofolate reductase (MTHFR) gene have been studied for correlation with bone mineral density (BMD) in 126 postmenopausal Maltese women (55.6 ± 7.1 years). All polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while BMD at the lumbar spine (LS), femoral neck (FN), Ward’s triangle and trochanter was measured by dual energy X-ray absorptiometry (DEXA). The observed genotype frequencies were similar to those in other populations and were in Hardy-Weinberg equilibrium. No association was observed between polymorphisms in the COL1A1 gene and BMD, even after adjustment for age, body mass index (BMI) and years since menopause. The Callele of the C677T variant of the MTHFR gene had a negative effect on trochanter BMD when testing for genetic models of dominant and recessive alleles (independent sample t-test: p = 0.03). Genotype frequencies of both genes did not differ significantly between normal women and those with a low BMD at either the LS or FN. | en_GB |
dc.language.iso | en | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Bone mineral density | en_GB |
dc.subject | Osteoporosis | en_GB |
dc.subject | Postmenopause | en_GB |
dc.subject | Genetic polymorphisms -- Malta | en_GB |
dc.title | Effects of SNPs in the COL1A1 and methylenetetrahydrofolate reductase genes on BMD in postmenopausal women in Malta | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | N/A | en_GB |
dc.contributor.creator | Vidal, Christopher | |
dc.contributor.creator | Brincat, Mark P. | |
dc.contributor.creator | Xuereb-Anastasi, Angela | |
Appears in Collections: | Scholarly Works - FacHScABS Scholarly Works - FacM&SOG |
Files in This Item:
File | Description | Size | Format | |
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Angela Xuereb - EFFECTS OF SNPs IN THE COL1A1 AND.pdf | 375.57 kB | Adobe PDF | View/Open |
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