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DC Field | Value | Language |
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dc.contributor.author | Gerada, Jurgen | - |
dc.contributor.author | Borg, Elaine | - |
dc.contributor.author | Formosa, Denise | - |
dc.contributor.author | Magro, Rosalie | - |
dc.contributor.author | Pocock, James | - |
dc.date.accessioned | 2019-12-04T15:04:47Z | - |
dc.date.available | 2019-12-04T15:04:47Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Gerada, J., Borg, E., Formosa, D., Magro, R., & Pocock, J. (2013). Tenofovir as rescue therapy following clinical failure to Lamivudine in severe acute hepatitis B. Mediterranean Journal of Hematology and Infectious Diseases, 5(1), 1-5. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/49310 | - |
dc.description.abstract | Acute hepatitis B (AHB) is a self-limiting condition in more than 95% of cases. Treatment is however recommended in patients with severe AHB (<1% of cases), aiming to prevent liver failure and death. Various nucleos(t)ide analogues (NA) have been found to be effective in severe AHB, although NA-resistant strains causing AHB have been also recently reported. The use of tenofovir in severe AHB has only been described in 3 cases (1 adult and 1 infant with HBV mono-infection, 1 adult with HBV/HIV co-infection). We hereby report a 47-year-old treatment-naïve male, who developed severe AHB and was initially treated with lamivudine (LMV). Initial rapid biochemical response was followed by biochemical breakthrough after 9 days, suggesting LMV resistance. Rescue therapy with ‘add-on’ tenofovir brought about a sustained improvement in biochemical, serological and virological markers until HBsAg was lost after 4 months. Thus, this is the second adult HBV mono-infected patient, who responded successfully to tenofovir in severe AHB. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Open Journal System | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Hepatitis B -- Diagnosis | en_GB |
dc.subject | Cell surface antigens | en_GB |
dc.subject | Clinical medicine -- Case studies | en_GB |
dc.title | Tenofovir as rescue therapy following clinical failure to lamivudine in severe acute hepatitis B | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.4084/MJHID.2013.035 | - |
dc.publication.title | Mediterranean Journal of Hematology and Infectious Diseases | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
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File | Description | Size | Format | |
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Tenofovir_as_rescue_therapy_following_clinical_failure_to_lamivudine_in_severe_acute_hepatitis_B.pdf | 370.15 kB | Adobe PDF | View/Open |
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