Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/53179
Title: | Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis |
Authors: | Heiss, Wolf-Dieter Dohmen, Christian Sobesky, Jan Kracht, Lutz Walter Bosche, Bert Staub, Frank Toyota, Shingo Valentino, Mario Graf, Rudolf |
Keywords: | Brain microdialysis Brain chemistry -- Physiology Brain -- Metabolism Cerebral circulation -- Regulation Intracranial pressure Flumazenil Excitatory amino acids Cerebral circulation |
Issue Date: | 2003 |
Publisher: | Springer Wien |
Citation: | Heiss, W. D., Dohmen, C., Sobesky, J., Kracht, L., Bosche, B., Staub, F., . . . Graf, R. (2003). Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis. Acta Neurochirurgica, Supplementum, 86, 237-240. doi:10.1007/978-3-7091-0651-8_51 |
Abstract: | Cerebral blood flow (CBF) and extent of irreversible tissue damage as well as the time course of extracellular concentration of amino acids, substrates of energy metabolism, and purine metabolites, intracranial pressure and tissue oxygen tension were assessed in 34 patients with large strokes covering more than 50% of the MCA territory. The results were compared to findings in the experimental model of transient (for 3 hours) MCA occlusion in cats. In the experimental model as well as in the clinical setting development of malignant brain infarcts (due to formation of space occupying brain edema) was predicted by the size of critically hypoperfused tissue and the volume of irreversibly damaged tissue. The course of malignant infarcts was characterized by progressive increase in concentrations of excitatory amino acids, lactate, pyruvate, glycerol, hypoxanthine and in intracranial pressure, while cerebral perfusion pressure and tissue oxygen tension decreased. These results clearly differentiate a malignant from a benign course of large hemispheric infarction. The methods can be used to identify patients at risk for formation of space occupying edema and to select patients who could benefit from invasive therapeutic strategies. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/53179 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
heiss2003.pdf Restricted Access | 932.51 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.