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https://www.um.edu.mt/library/oar/handle/123456789/53385
Title: | Neurochemical monitoring in malignant infarction |
Authors: | Toyota, Shingo Graf, Rudolf Valentino, Mario Fujinaka, Toshiyuki Yoshimine, Toshiki Hess, Wolf-Dieter |
Keywords: | Neurochemistry Diagnosis, Laboratory |
Issue Date: | 2004 |
Publisher: | Korean Stroke Society,Daehan Noejoljung Hakoe |
Citation: | Toyota, S., Graf, R., Valentino, M., Fujinaka, T., Yoshimine, T., & Hess, W. D. (2004). Neurochemical monitoring in malignant infarction. Japanese Journal of Stroke, 26(4), 524-529. |
Abstract: | To study the predictive significance of neurochemical monitoring in malignant infarction, we investigated the correlation between perfusional disturbances and neurochemical substances in a transient ischemia model in cats. METHODS: In 10 cats, the middle cerebral artery was occluded (MCAO) for 3 hours followed by 6 hours reperfusion. Microdialysis probes were inserted into the core and the perifocal site of the MCA territory. Concentrations of purine catabolites and amino acids were analyzed by HPLC. Adjacent to the micro dialysis probes, laser Doppler probes measured regional CBF (LDF), strain-gauge MicroSensors measured intracranial pressure (ICP). RESULTS: Later in the reperfusion period, five cats developed signs of malignant edema formation induding drastic drop of CPP, and finally pupil dilation. CONCLUSIONS: In the ischemic core, glutamate determinations during MCAO predict fatal outcome, not in the perifocal site. Secondary glutamate elevation during reperfusion is presumably caused by a drastic decrease of CPP to < 50 mmHg in the final stage of malignant infarction. However. this drop of CPP does not elevate adenosine. We assume that after reperfusion, salvage pathways are able to resynthesize IMP but not AMP. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/53385 |
ISSN: | 0912-0726 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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20b. Neurochemical monitoring in malignant edema. Japanese Journal of Stroke 26(4), 524-529..pdf | Paper | 316.07 kB | Adobe PDF | View/Open |
20a Neurochemical monitoring in malignant edema. Japanese Journal of Stroke 26(4), 524-529..pdf | 185.78 kB | Adobe PDF | View/Open |
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