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dc.identifier.citationValentino, M., Muscat, R., Bajada, C., & Ellul, B. (2009).Hypoglycemia causes widespread white matter injury – an imaging study in transgenic mice. 7th Malta Medical School Conference, St. Julians.en_GB
dc.description.abstractInsulin-induced hypoglycemia presents the most important limitation to effective treatment for diabetes. Acute severe hypoglycemia may cause transient or permanent brain dysfunction such as confusion, cognitive impairment, seizures and coma. Deprivation of cellular glucose also contributes to the pathophysiology of ischemic brain injury. Recent neuroimaging and pathological studies of patients with severe hypoglycemic episodes suggest that white matter is also vulnerable to hypoglycemia. Although hypoglycemic brain injury is well documented in gray matter, little is known of mechanisms of injury in white matter deprived of glucose. In this study, we investigated the time course in vivo of axon and oligodendrocyte injury in a model of cerebral white matter injury in acute brain slices from adult transgenic mice.en_GB
dc.publisherUniversity of Malta. Medical Schoolen_GB
dc.subjectWhite matteren_GB
dc.subjectDiabetes -- Treatmenten_GB
dc.subjectAcute diseasesen_GB
dc.titleHypoglycemia causes widespread white matter injury – an imaging study in transgenic miceen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.bibliographicCitation.conferencename7th Malta Medical School Conferenceen_GB
dc.bibliographicCitation.conferenceplaceSt. Julians, Malta, 05-07/11/2009en_GB
dc.contributor.creatorValentino, Mario-
dc.contributor.creatorMuscat, Richard-
dc.contributor.creatorBajada, Claude J.-
dc.contributor.creatorEllul, Bridget-
Appears in Collections:Scholarly Works - FacM&SPB

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