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DC Field | Value | Language |
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dc.contributor.author | Valentino, Mario | - |
dc.contributor.author | Vella, J. | - |
dc.contributor.author | Zammit, R. | - |
dc.contributor.author | Zammit, Christian | - |
dc.date.accessioned | 2020-04-08T12:29:13Z | - |
dc.date.available | 2020-04-08T12:29:13Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Valentino, M., Vella, J., Zammit, R., & Zammit, C. (2018). L-lactate reduces ischemic white matter injury and modulates HCA1 oligodendrocyte expression in an in vivo mouse model of focal ischemia. Malta Medical Journal, 30, 154 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/53889 | - |
dc.description.abstract | L-lactate is a metabolite that is oxidized preferentially to glucose under conditions of high metabolic stress. The discovery and localization of the lactate receptor HCA1 in various brain regions suggests that lactate is additionally an important signaling molecule in the brain. Lactate is neuroprotective in various ischemia paradigms, reduces axonal injury in vitro and is avidly utilized by oligodendrocytes (OLs). The protective potential of L-lactate to reduce white matter (WM) injury in a mouse stroke model was investigated. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | University of Malta. Medical School | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Transient ischemic attack | en_GB |
dc.subject | White matter | en_GB |
dc.subject | Oligodendroglia | en_GB |
dc.subject | Glucose -- Metabolism | en_GB |
dc.subject | Metabolic syndrome | en_GB |
dc.subject | Brain -- Research | en_GB |
dc.subject | Axons -- Diseases | en_GB |
dc.title | L-lactate reduces ischemic white matter injury and modulates HCA1 oligodendrocyte expression in an in vivo mouse model of focal ischemia | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.bibliographicCitation.conferencename | 10th Malta Medical School Conference | en_GB |
dc.bibliographicCitation.conferenceplace | St Julian's, Malta, 29/11 - 01/12/2018 | en_GB |
dc.description.reviewed | N/A | en_GB |
dc.publication.title | Malta Medical Journal | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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L_lactate_reduces_ischemic_white_matter_injury_and_modulates_HCA1_oligodendrocyte_expression_in_an_in_vivo_mouse_model_of_focal_ischemia.pdf | 86 kB | Adobe PDF | View/Open |
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