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dc.contributor.authorValentino, Mario-
dc.contributor.authorVella, J.-
dc.contributor.authorZammit, R.-
dc.contributor.authorZammit, Christian-
dc.identifier.citationValentino, M., Vella, J., Zammit, R., & Zammit, C. (2018). L-lactate reduces ischemic white matter injury and modulates HCA1 oligodendrocyte expression in an in vivo mouse model of focal ischemia. Malta Medical Journal, 30, 154en_GB
dc.description.abstractL-lactate is a metabolite that is oxidized preferentially to glucose under conditions of high metabolic stress. The discovery and localization of the lactate receptor HCA1 in various brain regions suggests that lactate is additionally an important signaling molecule in the brain. Lactate is neuroprotective in various ischemia paradigms, reduces axonal injury in vitro and is avidly utilized by oligodendrocytes (OLs). The protective potential of L-lactate to reduce white matter (WM) injury in a mouse stroke model was investigated.en_GB
dc.publisherUniversity of Malta. Medical Schoolen_GB
dc.subjectTransient ischemic attacken_GB
dc.subjectWhite matteren_GB
dc.subjectGlucose -- Metabolismen_GB
dc.subjectMetabolic syndromeen_GB
dc.subjectBrain -- Researchen_GB
dc.subjectAxons -- Diseasesen_GB
dc.titleL-lactate reduces ischemic white matter injury and modulates HCA1 oligodendrocyte expression in an in vivo mouse model of focal ischemiaen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.bibliographicCitation.conferencename10th Malta Medical School Conferenceen_GB
dc.bibliographicCitation.conferenceplaceSt Julian's, Malta, 29/11 - 01/12/2018en_GB
dc.publication.titleMalta Medical Journalen_GB
Appears in Collections:Scholarly Works - FacM&SPB

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