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DC Field | Value | Language |
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dc.contributor.author | Casha, Aaron R. | - |
dc.contributor.author | Bertolaccini, Luca | - |
dc.contributor.author | Camilleri, Liberato | - |
dc.contributor.author | Manche, Alexander | - |
dc.contributor.author | Gauci, Marilyn | - |
dc.contributor.author | Melikyan, Gor | - |
dc.contributor.author | Gatt, Ruben | - |
dc.contributor.author | Dudek, Krzysztof | - |
dc.contributor.author | Solli, Piergiorgio | - |
dc.contributor.author | Grima, Joseph N. | - |
dc.date.accessioned | 2020-05-13T09:50:17Z | - |
dc.date.available | 2020-05-13T09:50:17Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Casha, A. R., Bertolaccini, L., Camilleri, L., Manche, A., Gauci, M., Melikyan, G., ... & Grima, J. N. (2018). Pathophysiological mechanism of post-lobectomy air leaks. Journal of Thoracic Disease, 10(6), 3689. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/55965 | - |
dc.description.abstract | Background: Air leak post-lobectomy continues to remain a significant clinical problem, with upper lobectomy associated with higher air leak rates. This paper investigated the pathophysiological role of pleural stress in the development of post-lobectomy air leak. | en_GB |
dc.description.abstract | Methods: Preoperative characteristics and postoperative data from 367 consecutive video assisted thoracic surgery (VATS) lobectomy resections from one centre were collected prospectively between January 2014 and March 2017. Computer modelling of a lung model using finite element analysis (FEA) was used to calculate pleural stress in differing areas of the lung. | en_GB |
dc.description.abstract | Results: Air leak following upper lobectomy was significantly higher than after middle or lower lobectomy (6.3% versus 2.5%, P=0.044), resulting in a significant six-day increase in mean hospital stay, P=0.004. The computer simulation model of the lung showed that an apical bullet shape was subject to eightyfold higher stress than the base of the lung model. | en_GB |
dc.description.abstract | Conclusions: After upper lobectomy, the bullet shape of the apex of the exposed lower lobe was associated with high pleural stress, and a reduction in mechanical support by the chest wall to the visceral pleura due to initial post-op lack of chest wall confluence. It is suggested that such higher stress in the lower lobe apex explains the higher parenchymal air leak post-upper lobectomy. The pleural stress model also accounts for the higher incidence of right-sided prolonged air leak post-resection. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Pioneer Bioscience Publishing Company | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Biomechanics | en_GB |
dc.subject | Temporal lobectomy | en_GB |
dc.subject | Chest -- Surgery | en_GB |
dc.subject | Chest -- Endoscopic surgery | en_GB |
dc.title | Pathophysiological mechanism of post-lobectomy air leaks | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.21037/jtd.2018.05.116 | - |
dc.publication.title | Journal of Thoracic Disease | en_GB |
Appears in Collections: | Scholarly Works - FacSciSOR |
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File | Description | Size | Format | |
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Pathophysiological_mechanism_of_post_lobectomy_air_leaks.pdf | 707.65 kB | Adobe PDF | View/Open |
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