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DC Field | Value | Language |
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dc.contributor.author | Calleja-Agius, Jean | - |
dc.contributor.author | Jauniaux, Eric R.M. | - |
dc.contributor.author | Muttukrishna, Shanthi | - |
dc.date.accessioned | 2020-07-03T08:40:34Z | - |
dc.date.available | 2020-07-03T08:40:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Calleja-Agius, J., Jauniaux, E., & Muttukrishna, S. (2012). Placental villous expression of TNF α and IL‐10 and effect of oxygen tension in euploid early pregnancy failure. American Journal of Reproductive Immunology, 67(6), 515-525. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/58519 | - |
dc.description.abstract | Problem: The objective was to investigate placental inflammation in chromosomally normal miscarriages in vivo and in vitro. Method of study: Chorionic villous tissue was collected from missed miscarriages and normal gestation-matched controls and cultured at 6 and 20% O2 concentrations. Tissue was karyotyped. Flowcytometric bead arrays and real-time PCR were carried out for protein and gene expression studies. Results: The levels of TNFα and IL-10 were significantly (P < 0.005 and P < 0.05) higher, and the levels of TNF-R1 and TNF-R2 were significantly (P < 0.01 and P < 0.05) lower in culture conditioned medium of villous explants of miscarriages compared to control group. Villous tissue homogenates from miscarriages contained significantly (P < 0.005) lower levels of TNF-R1. There was a significant O2-dependent increase in the secretion of IL-10 (P < 0.01) and decrease in TNFα/IL-10 ratio (P < 0.005) in the culture medium in both groups. Conclusion: Increased levels of TNFα and decreased levels of receptors in miscarriage villous tissue confirm an excessive placental inflammation in miscarriage patients. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Wiley-Blackwell Publishing, Inc. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Interleukin-10 | en_GB |
dc.subject | Miscarriage | en_GB |
dc.subject | Placenta | en_GB |
dc.subject | Tumor necrosis factor -- Receptors | en_GB |
dc.title | Placental villous expression of TNF α and IL‐10 and effect of oxygen tension in euploid early pregnancy failure | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1111/j.1600-0897.2012.01104.x | - |
dc.publication.title | American Journal of Reproductive Immunology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SAna |
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