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DC Field | Value | Language |
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dc.contributor.author | Calleja-Agius, Jean | - |
dc.contributor.author | Muttukrishna, Shanthi | - |
dc.contributor.author | Jauniaux, Eric R.M. | - |
dc.date.accessioned | 2020-07-03T10:30:33Z | - |
dc.date.available | 2020-07-03T10:30:33Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Calleja-Agius, J., Muttukrishna, S., & Jauniaux, E. (2012). The role of tumor necrosis factor-receptors in pregnancy with normal and adverse outcome. International Journal of Interferon, Cytokine and Mediator Research, 4, 1-5. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/58534 | - |
dc.description.abstract | TNFα receptors, TNF-R1 and TNF-R2, mediate the biological activities of the multifunctional cytokine, tumor necrosis factor alpha, TNFα. These receptors have a central role in human pregnancy. Although each receptor induces distinct intracellular signals, they also have co-operative and overlapping effects. The membrane bound TNF-R1 carries out most of the pro-inflammatory activities of TNFα, especially those that are rapid, while TNF-R2 is involved in the late long-term effects of this cytokine. The soluble forms of these receptors can bind to TNFα, neutralizing its effects. In normal human pregnancy, TNFα receptors are present in the maternal circulation, placenta, amniotic fluid, and coelomic cavity. Changes in TNFα and its receptors are associated with adverse pregnancy outcomes, including miscarriage, preterm labor and preeclampsia. Advances in anti-TNFα therapy may have potential use in the management of complicated pregnancies. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Dove Medical Press Ltd.(Dovepress) | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Tumor necrosis factor -- Receptors | en_GB |
dc.subject | Miscarriage | en_GB |
dc.subject | Pregnancy | en_GB |
dc.subject | Preeclampsia | en_GB |
dc.subject | Premature labor | en_GB |
dc.title | The role of tumor necrosis factor-receptors in pregnancy with normal and adverse outcome | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.2147/IJICMR.S22848 | - |
dc.publication.title | International Journal of Interferon, Cytokine and Mediator Research | en_GB |
Appears in Collections: | Scholarly Works - FacM&SAna |
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