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dc.contributor.authorCuschieri, Alfred-
dc.contributor.authorSaid, Edith-
dc.contributor.authorCalleja-Agius, Jean-
dc.date.accessioned2020-07-14T11:23:02Z-
dc.date.available2020-07-14T11:23:02Z-
dc.date.issued2004-
dc.identifier.citationCuschieri, A., Said, E., & Calleja-Agius, J. (2004). Defect in dorso-ventral patterning, asplenia, and conotruncus in a spontaneously aborted fetus. Fetal and Pediatric Pathology, 23(4), 265-274.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/58733-
dc.description.abstractWe describe a very unusual combination, and previously unreported, of malformations in an 18-week, spontaneously aborted male fetus. The fetus had a reversed dorsoventral positioning of the head and upper limbs relative to the body axis with the head and both upper limbs directed dorsally, and an abrupt rotation of the vertebral bones at the level of C7. The fetus also had asplenia, single ventricle, and conotruncus. The fetus also had flexion deformities at the wrist, reduction deformity of the left second digit, anomalies in ossification of the bones of the left hand, and bilateral talipes calcaneovalgus. The major malformations in this fetus were all blastogenetic in origin and consisted of dorsoventral patterning defect involving structures cranial to C7, a laterality, and a septation defect of the ventricle and outflow tract of the heart. The defects are interpreted as being the result of abnormal coordination of the molecular signaling involved in dorsoventral axis formation and laterality of the limbs and trunk, and possibly also in cardiac septation.en_GB
dc.language.isoenen_GB
dc.publisherTaylor & Francisen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectFetus -- Abnormalitiesen_GB
dc.subjectSpleen -- Diseasesen_GB
dc.subjectFetus -- Developmenten_GB
dc.subjectFetus -- Diseasesen_GB
dc.subjectFetal heart -- Abnormalitiesen_GB
dc.titleDefect in dorso-ventral patterning, asplenia, and conotruncus in a spontaneously aborted fetusen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1080/15227950490923697-
dc.publication.titleFetal and Pediatric Pathologyen_GB
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