Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/58855
Title: Synthetic drugs of abuse exhibiting kinetic and non-kinetic toxicology
Authors: Xuereb, Sarah
Keywords: Drugs of abuse
Synthetic drugs
Toxicology
Issue Date: 2019
Citation: Xuereb, S. (2019). Synthetic drugs of abuse exhibiting kinetic and non-kinetic toxicology (Bachelor's dissertation).
Abstract: Kinetic toxicology can occur following absorption, distribution, metabolism and excretion of a drug and non-kinetic toxicological effects occur at the exposure site of the drug. The purpose of the study was to analyse and compare the kinetic and non-kinetic toxicological effects following the use of cocaine, 3,4-Methylenedioxymethamphetamine and synthetic cannabinoids and to relate kinetic and non-kinetic toxicological effects to clinical scenarios. Literature review was carried out on the kinetic and non-kinetic toxicology of cocaine, MDMA and synthetic cannabinoids. The study included open-access journal articles published between January 1998 and December 2018. Chest pain (n=19), hyperthermia (n=13) and nausea (n=9) were the most commonly reported kinetic toxicological effects of cocaine and destruction of the nasal septum (n=8) and necrosis (n=4) were the most commonly reported non-kinetic toxicological effects. Seizures (n=13), agitation (n=10) and emesis (n=9) were the most commonly reported kinetic toxicological effects of MDMA and pneumomediastinum (n=2) and necrosis (n=2) were the most commonly reported non-kinetic toxicological effects of MDMA. Emesis (n=108), nausea (n=106) and tachycardia (n=86) were the most commonly reported kinetic effects of the synthetic cannabinoid JWH-018. No non-kinetic effects for synthetic cannabinoids were identified. Knowledge of kinetic and non-kinetic toxicology of drugs of abuse can help create awareness about the ill effects that these drugs may cause and can provide the clinician with more information about treatment and prevention of associated complications.
Description: B.PHARM.(HONS)
URI: https://www.um.edu.mt/library/oar/handle/123456789/58855
Appears in Collections:Dissertations - FacM&S - 2019
Dissertations - FacM&SPha - 2019

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