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DC Field | Value | Language |
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dc.contributor.author | Jackson, Rebecca L. | - |
dc.contributor.author | Bajada, Claude J. | - |
dc.contributor.author | Lambon Ralph, Matthew A. | - |
dc.contributor.author | Cloutman, Lauren L. | - |
dc.date.accessioned | 2020-07-17T09:29:59Z | - |
dc.date.available | 2020-07-17T09:29:59Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Jackson, R. L., Bajada, C. J., Lambon Ralph, M. A., & Cloutman, L. L. (2020). The graded change in connectivity across the ventromedial prefrontal cortex reveals distinct subregions. Cerebral Cortex, 30(1), 165-180. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/58885 | - |
dc.description.abstract | The functional heterogeneity of the ventromedial prefrontal cortex (vmPFC) suggests it may include distinct functional subregions. To date these have not been well elucidated. Regions with differentiable connectivity (and as a result likely dissociable functions) may be identified using emergent data-driven approaches. However, prior parcellations of the vmPFC have only considered hard splits between distinct regions, although both hard and graded connectivity changes may exist. Here we determine the full pattern of change in structural and functional connectivity across the vmPFC for the first time and extract core distinct regions. Both structural and functional connectivity varied along a dorsomedial to ventrolateral axis from relatively dorsal medial wall regions to relatively lateral basal orbitofrontal cortex. The pattern of connectivity shifted from default mode network to sensorimotor and multimodal semantic connections. This finding extends the classical distinction between primate medial and orbital regions by demonstrating a similar gradient in humans for the first time. Additionally, core distinct regions in the medial wall and orbitofrontal cortex were identified that may show greater correspondence to functional differences than prior hard parcellations. The possible functional roles of the orbitofrontal cortex and medial wall are discussed. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Oxford University Press | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Optical data processing | en_GB |
dc.subject | Visualization | en_GB |
dc.subject | Brain -- Concussion | en_GB |
dc.subject | Cognition | en_GB |
dc.subject | Human locomotion | en_GB |
dc.subject | Prefrontal cortex | en_GB |
dc.subject | Cognitive neuroscience | en_GB |
dc.title | The graded change in connectivity across the ventromedial prefrontal cortex reveals distinct subregions | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1093/cercor/bhz079 | - |
dc.publication.title | Cerebral Cortex | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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File | Description | Size | Format | |
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The Graded Change in Connectivity across the Ventromedial Prefrontal Cortex Reveals Distinct Subregions.pdf | 995.19 kB | Adobe PDF | View/Open |
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