Please use this identifier to cite or link to this item:
Title: Menopause-related changes in the musculoskeletal system, cartilages and joints
Other Titles: Frontiers in gynecological endocrinology : volume 1 : from symptoms to therapies
Authors: Brincat, Mark
Calleja-Agius, Jean
Keywords: Bones -- Diseases
Issue Date: 2014
Publisher: Springer International Publishing
Citation: Calleja-Agius, J., & Brincat, M. (2014). Menopause-related changes in the musculoskeletal system, cartilages and joints. In A. R. Genazzini & M. Brincat (Eds.), Frontiers in gynecological endocrinology : volume 1 : from symptoms to therapies (pp. 201-205). New York: Springer International.
Abstract: Osteoporosis and related fractures are a significant concern for the global community. As the population continues to age, morbidity and mortality from fractures due to osteoporosis will likely continue to increase. The menopause has been shown repeatedly to have a negative effect on the connective tissue in the bone matrix. Such an effect is prevented and in some cases reversed with oestrogen therapy. Studies show that oestrogen prevents osteoporosis partly by inhibiting bone resorption. Selective oestrogen receptor modulators (SERMs) act through oestrogen receptors and are agonists for bone and antagonists for breast and uterine tissue. A new approach to menopausal therapy is the tissue selective oestrogen complex or the pairing of a selective oestrogen receptor modulator with oestrogens. Novel bone-targeting oestradiol delivery systems have the potential to improve the safety profile of oestradiol in the treatment of osteoporosis.
Appears in Collections:Scholarly Works - FacM&SAna

Files in This Item:
File Description SizeFormat 
  Restricted Access
117.82 kBAdobe PDFView/Open Request a copy

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.