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dc.contributor.authorBrincat, Mark-
dc.contributor.authorCalleja-Agius, Jean-
dc.identifier.citationCalleja-Agius, J., & Brincat, M. (2014). Menopause-related changes in the musculoskeletal system, cartilages and joints. In A. R. Genazzini & M. Brincat (Eds.), Frontiers in gynecological endocrinology : volume 1 : from symptoms to therapies (pp. 201-205). New York: Springer International.en_GB
dc.description.abstractOsteoporosis and related fractures are a significant concern for the global community. As the population continues to age, morbidity and mortality from fractures due to osteoporosis will likely continue to increase. The menopause has been shown repeatedly to have a negative effect on the connective tissue in the bone matrix. Such an effect is prevented and in some cases reversed with oestrogen therapy. Studies show that oestrogen prevents osteoporosis partly by inhibiting bone resorption. Selective oestrogen receptor modulators (SERMs) act through oestrogen receptors and are agonists for bone and antagonists for breast and uterine tissue. A new approach to menopausal therapy is the tissue selective oestrogen complex or the pairing of a selective oestrogen receptor modulator with oestrogens. Novel bone-targeting oestradiol delivery systems have the potential to improve the safety profile of oestradiol in the treatment of osteoporosis.en_GB
dc.publisherSpringer International Publishingen_GB
dc.subjectBones -- Diseasesen_GB
dc.titleMenopause-related changes in the musculoskeletal system, cartilages and jointsen_GB
dc.title.alternativeFrontiers in gynecological endocrinology : volume 1 : from symptoms to therapiesen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
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