Please use this identifier to cite or link to this item:
Title: An update on the genetics of pre-eclampsia
Authors: Agius, Andee
Sultana, Roberta
Camenzuli, Christian
Calleja-Agius, Jean
Balzan, Rena
Keywords: Preeclampsia
Issue Date: 2018
Publisher: Edizioni Minerva Medica
Citation: Agius, A., Sultana, R., Camenzuli, C., Calleja-Agius, J., & Balzan, R. (2018). An update on the genetics of pre-eclampsia. Minerva Ginecologica, 70(4), 465-479.
Abstract: Pre-eclampsia is a progressive multisystem disorder that is exclusive to human pregnancy and defined as new hypertension presenting after 20 weeks with significant proteinuria. It is a multifactorial condition with a strong genetic component and several genes have been linked with this disorder. The main players implicated in the pathogenesis of pre-eclampsia include immune maladaptation, hemodynamics, endothelial function, thrombophilic disorders, oxidative stress and lipid metabolism. All of these mechanisms encompass genetic factors that might be responsible for the pathogenic changes taking place. Pre-eclampsia has been referred to as a primipaternity disease. A number of studies examined the contribution of paternal genes in pre-eclampsia. Although there is evidence that paternal genes significantly increase the risk of pre-eclampsia, there is still inconclusive evidence whether having the same partner is a protective factor. Gene expression, through imprinting and epistasis, also play an important role in the pathogenesis of this disorder. Pre-eclampsia remains a disease of theories. Despite the growing body of research exploring this complex disorder, the etiology of pre-eclampsia remains elusive and the struggle is still ongoing to find an effective predictive test that can detect this disorder at an early stage where intervention can prevent the progression of the disorder. Research is still ongoing. Prevention and early detection of pre-eclampsia remain the ultimate goal.
Appears in Collections:Scholarly Works - FacM&SAna

Files in This Item:
File Description SizeFormat 
  Restricted Access
869.44 kBAdobe PDFView/Open Request a copy

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.