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dc.contributor.authorCuschieri, Andrea-
dc.contributor.authorCalleja-Agius, Jean-
dc.identifier.citationCuschieri, A., & Calleja-Agius, J. (2020). Wnt/PCP signalling cascade disruption by JNK inhibition as a potential mechanism underlying the teratogenic effects of potato glycoalkaloids. Molecular Biology Reports, 10.1007/s11033-020-05921-6.en_GB
dc.description.abstractIt is hypothesised that the inhibition of the non-canonical Wnt/PCP intracellular signalling cascade by potato glycoalkaloids, α-solanine and α-chaconine, results in an increased risk of neural tube defects (NTDs). One very prominent intracellular signalling pathway with substantial implications in the development and closure of the neural tube is the Wnt/PCP pathway. Experimental inhibition of this results in NTDs. A vital element of this signalling cascade is JNK, which controls the transcription of DNA, which controls cell polarity and directional cell migration. JNK inhibition also results in NTDs experimentally. Through their use in cancer research, α-solanine and α-chaconine were found to inhibit metastasis by inhibiting JNK, among other intracellular signalling molecules. Thus, this shows that potato glycoalkaloids increase the likelihood of causing NTDs by inhibiting the proper functioning of JNK in the Wnt/PCP pathway, resulting in defective neural tube closure.en_GB
dc.publisherSpringer Netherlandsen_GB
dc.subjectNeural tube -- Abnormalitiesen_GB
dc.subjectJNK mitogen-activated protein kinasesen_GB
dc.subjectWnt proteinsen_GB
dc.titleWnt/PCP signalling cascade disruption by JNK inhibition as a potential mechanism underlying the teratogenic effects of potato glycoalkaloidsen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleMolecular Biology Reportsen_GB
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