Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/6345
Title: | Pro- and anti-inflammatory cytokines in threatened miscarriages |
Authors: | Calleja-Agius, Jean Muttukrishna, Shanthi Pizzey, Arnold R. Jauniaux, Eric R.M. |
Keywords: | Cytokines -- Pathophysiology Pregnancy -- Complications Tumor necrosis factor |
Issue Date: | 2011 |
Citation: | American Journal of Obstetrics & Gynecology. 2011, Vol.205, p. 83.e8–83.e16 |
Abstract: | OBJECTIVE: The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatenedmiscarriage (TM) and subsequent outcome. STUDY DESIGN: Plasma levels of tumor necrosis factor (TNF)-receptors 1 and 2, TNF , interferon gamma (IFN ), and interleukins (IL) -6 and -10 were measured by flow cytometric bead assays in 80 women with TM: 53 women with normal outcome and 27 women who miscarried. Fluorescent antibody labeling was also performed on whole blood in a subgroup of 27 women of TM: 16 women with normal outcome and 11 women who miscarried. RESULTS: Monocyte expression of TNF and circulating levels of TNF , IFN , IL-10, IL-6, and TNF-R1 were significantly lower, whereas circulating levels of TNF /IL-10, IFN /IL-10, and TNF /IL-6 ratios were significantly higher, in women with TM who subsequently miscarried, compared with the women with normal outcome. CONCLUSION: An increased Th1 type of immune response, which was similar to that observed in preterm delivery, was found in TM cases that were complicated by a subsequent miscarriage. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/6345 |
Appears in Collections: | Scholarly Works - FacM&SAna |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Jean Calleja-Agius - Pro- and antiinflammatory cytokines in threatened miscarriages.pdf | 471.61 kB | Adobe PDF | View/Open |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.