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DC Field | Value | Language |
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dc.contributor.author | Calleja-Agius, Jean | - |
dc.contributor.author | Muttukrishna, Shanthi | - |
dc.contributor.author | Pizzey, Arnold R. | - |
dc.contributor.author | Jauniaux, Eric R.M. | - |
dc.date.accessioned | 2015-11-11T13:19:49Z | - |
dc.date.available | 2015-11-11T13:19:49Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | American Journal of Obstetrics & Gynecology. 2011, Vol.205, p. 83.e8–83.e16 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/6345 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatenedmiscarriage (TM) and subsequent outcome. STUDY DESIGN: Plasma levels of tumor necrosis factor (TNF)-receptors 1 and 2, TNF , interferon gamma (IFN ), and interleukins (IL) -6 and -10 were measured by flow cytometric bead assays in 80 women with TM: 53 women with normal outcome and 27 women who miscarried. Fluorescent antibody labeling was also performed on whole blood in a subgroup of 27 women of TM: 16 women with normal outcome and 11 women who miscarried. RESULTS: Monocyte expression of TNF and circulating levels of TNF , IFN , IL-10, IL-6, and TNF-R1 were significantly lower, whereas circulating levels of TNF /IL-10, IFN /IL-10, and TNF /IL-6 ratios were significantly higher, in women with TM who subsequently miscarried, compared with the women with normal outcome. CONCLUSION: An increased Th1 type of immune response, which was similar to that observed in preterm delivery, was found in TM cases that were complicated by a subsequent miscarriage. | en_GB |
dc.language.iso | en | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Cytokines -- Pathophysiology | en_GB |
dc.subject | Pregnancy -- Complications | en_GB |
dc.subject | Tumor necrosis factor | en_GB |
dc.title | Pro- and anti-inflammatory cytokines in threatened miscarriages | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.ajog.2011.02.051 | - |
Appears in Collections: | Scholarly Works - FacM&SAna |
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Jean Calleja-Agius - Pro- and antiinflammatory cytokines in threatened miscarriages.pdf | 471.61 kB | Adobe PDF | View/Open |
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