Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/65371
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dc.contributor.authorBordoni, Laura-
dc.contributor.authorPetracci, Irene-
dc.contributor.authorCalleja-Agius, Jean-
dc.contributor.authorLalor, Joan G.-
dc.contributor.authorGabbianelli, Rosita-
dc.date.accessioned2020-12-09T09:04:34Z-
dc.date.available2020-12-09T09:04:34Z-
dc.date.issued2020-
dc.identifier.citationBordoni, L., Petracci, I., Calleja-Agius, J., Lalor, J. G., & Gabbianelli, R. (2020). NURR1 alterations in perinatal stress : a first step towards late‐onset diseases? A narrative review. Biomedicines, 8, 584.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/65371-
dc.description.abstractPerinatal life represents a delicate phase of development where stimuli of all sorts, coming to or from the mother, can influence the programming of the future baby’s health. These stimuli may have consequences that persist throughout adulthood. Nuclear receptor related 1 protein (NURR1), a transcription factor with a critical role in the development of the dopaminergic neurons in the midbrain, mediates the response to stressful environmental stimuli in the perinatal period. During pregnancy, low‐grade inflammation triggered by maternal obesity, hyperinsulinemia or vaginal infections alters NURR1 expression in human gestational tissues. A similar scenario is triggered by exposure to neurotoxic compounds, which are associated with NURR1 epigenetic deregulation in the offspring, with potential intergenerational effects. Since these alterations have been associated with an increased risk of developing late‐onset diseases in children, NURR1, alone, or in combination with other molecular markers, has been proposed as a new prognostic tool and a potential therapeutic target for several pathological conditions. This narrative review describes perinatal stress associated with NURR1 gene deregulation, which is proposed here as a mediator of late‐onset consequences of early life events.en_GB
dc.language.isoenen_GB
dc.publisherMDPI AGen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectInflammationen_GB
dc.subjectStress (Psychology)en_GB
dc.subjectMaternal health servicesen_GB
dc.titleNURR1 alterations in perinatal stress : a first step towards late‐onset diseases? A narrative reviewen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.3390/biomedicines8120584-
dc.publication.titleBiomedicinesen_GB
Appears in Collections:Scholarly Works - FacM&SAna



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