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dc.contributor.authorAzzopardi, Ernest A.-
dc.contributor.authorRodrigues Teixeira, Rosa Sofia-
dc.contributor.authorConlan, Robert Steven-
dc.contributor.authorWhitaker, Iain S.-
dc.identifier.citationAzzopardi, E. A., Lloyd, C., Rodrigues Teixeira, S., Conlan, R. S., & Whitaker, I. S. (2016). Clinical applications of amylase: novel perspectives. Surgery, 160(1), 26-37.en_GB
dc.description.abstractBackground: Amylase was the first enzyme to be characterized, and for the previous 200 years, its clinical role has been restricted to a diagnostic aid. Recent interface research has led to a substantial expansion of its role into novel, viable diagnostic, and therapeutic applications to cancer, infection, and wound healing. This review provides a concise “state-of–the-art” overview of the genetics, structure, distribution, and localization of amylase in humans. Method: A first-generation literature search was performed with the MeSH search string “Amylase AND (diagnost∗ OR therapeut$)” on OVIDSP and PUBMED platforms. A second-generation search was then performed by forward and backward referencing on Web of Knowledge™ and manual indexing, limited to the English Language. Results: “State of the Art” in amylase genetics, structure, function distribution, localisation and detection of amylase in humans is provided. To the 4 classic patterns of hyperamylasemia (pancreatic, salivary, macroamylasemia, and combinations) a fifth, the localized targeting of amylase to specific foci of infection, is proposed. Conclusions: The implications are directed at novel therapeutic and diagnostic clinical applications of amylase such as the novel therapeutic drug classes capable of targeted delivery and “smart release” in areas of clinical need. Future directions of research in areas of high clinical benefit are reported.en_GB
dc.subjectAmylases -- Therapeutic useen_GB
dc.subjectAmylases -- Inhibitorsen_GB
dc.subjectAmylases -- Analysisen_GB
dc.subjectEnzymes -- Analysisen_GB
dc.subjectPancreas -- Diseases -- Diagnosisen_GB
dc.subjectDigestive enzymesen_GB
dc.titleClinical applications of amylase : novel perspectivesen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
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