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dc.contributor.authorAzzopardi, Ernest A.-
dc.contributor.authorConlan, R. Steven-
dc.contributor.authorWhitaker, Iain S.-
dc.identifier.citationAzzopardi, E. A., Conlan, R. S., & Whitaker, I. S. (2016). Polymer therapeutics in surgery: the next frontier. Journal of Interdisciplinary Nanomedicine, 1(1), 19-29.en_GB
dc.description.abstractPolymer therapeutics is a successful branch of nanomedicine, which is now established in several facets of everyday practice. However, to our knowledge, no literature regarding the application of the underpinning principles, general safety, and potential of this versatile class to the perioperative patient has been published. This study provides an overview of polymer therapeutics applied to clinical surgery, including the evolution of this demand-oriented scientific field, cutting-edge concepts, its implications, and limitations, illustrated by products already in clinical use and promising ones in development. In particular, the effect of design of polymer therapeutics on biophysical and biochemical properties, the potential for targeted delivery, smart release, and safety are addressed. Emphasis is made on principles, giving examples in salient areas of demand in current surgical practice. Exposure of the practising surgeon to this versatile class is crucial to evaluate and maximise the benefits that this established field presents and to attract a new generation of clinician–scientists with the necessary knowledge mix to drive highly successful innovation.en_GB
dc.publisherJohn Wiley & Sons Ltd.en_GB
dc.subjectPolymers -- Therapeutic useen_GB
dc.subjectPolymeric drug delivery systemsen_GB
dc.subjectPolymers in medicineen_GB
dc.subjectSurgery, Operativeen_GB
dc.titlePolymer therapeutics in surgery : the next frontieren_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleJournal of Interdisciplinary Nanomedicineen_GB
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