Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/70953
Title: A novel class of bioresponsive nanomedicines for localised reinstatement of bioactivity and specific targeting
Authors: Azzopardi, Ernest A.
Ferguson, Elaine
Thomas, David
Keywords: Gram-negative bacteria
Antibacterial agents
Colistin -- Therapeutic use
Nanomedicine
Issue Date: 2014
Publisher: Elsevier
Citation: Azzopardi, E., Ferguson, E., & Thomas, D. (2014). A novel class of bioresponsive nanomedicines for localised reinstatement of bioactivity and specific targeting. The Lancet, 383: S9.
Abstract: Gram-negative infection is a global health concern. We present a custom-engineered, novel, patented, dextrin-colistin conjugate that can mask the toxicity of colistin; this conjugate allows controlled, enzymatically mediated dextrin degradation (unmasking) and reinstatement of colistin activity at the infected site. In the presence of amylase, the lead candidate EA-4 (1·0 mol% succinoylation, 11·2 % w/w colistin, molecular weight ~10 300 g/mol) maximally unmasked and was equally eff ective to the clinical colistin formulation against strains of multidrug resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae (minimum inhibitory concentration ≤4 g/L), but suppression of bacterial viability was six times longer. Here we report ex-vivo and in-vivo activity, pharmacokinetics and pharmacodynamics, and toxicity.
Description: Young Investigator Award Abstracts
URI: https://www.um.edu.mt/library/oar/handle/123456789/70953
Appears in Collections:Scholarly Works - FacM&SAna



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