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dc.contributor.authorFiore, Riccardo Di-
dc.contributor.authorSuleiman, Sherif-
dc.contributor.authorFelix, Ana-
dc.contributor.authorO’Toole, Sharon A.-
dc.contributor.authorO’Leary, John J.-
dc.contributor.authorWard, Mark P.-
dc.contributor.authorBeirne, James P.-
dc.contributor.authorSabol, Maja-
dc.contributor.authorOzretić, Petar-
dc.contributor.authorYordanov, Angel-
dc.contributor.authorVasileva-Slaveva, Mariela-
dc.contributor.authorKostov, Stoyan-
dc.contributor.authorNikolova, Margarita-
dc.contributor.authorSaid-Huntingford, Ian-
dc.contributor.authorAyers, Duncan-
dc.contributor.authorEllul, Bridget-
dc.contributor.authorPentimalli, Francesca-
dc.contributor.authorGiordano, Antonio-
dc.contributor.authorCalleja-Agius, Jean-
dc.date.accessioned2021-06-22T07:30:41Z-
dc.date.available2021-06-22T07:30:41Z-
dc.date.issued2021-
dc.identifier.citationDi Fiore, R., Suleiman, S., Felix, A., O’Toole, S. A., O’Leary, J. J., Ward, M. P.,…Calleja-Agius, J. (2021). An overview of the role of long non-coding RNAs in human choriocarcinoma. International Journal of Molecular Sciences, 22(12), 6506.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/77534-
dc.description.abstractChoriocarcinoma (CC), a subtype of trophoblastic disease, is a rare and highly aggressive neoplasm. There are two main CC subtypes: gestational and non-gestational, (so called when it develops as a component of a germ cell tumor or is related to a somatic mutation of a poorly differentiated carcinoma), each with very diverse biological activity. A therapeutic approach is highly effective in patients with early-stage CC. The advanced stage of the disease also has a good prognosis with around 95% of patients cured following chemotherapy. However, advancements in diagnosis and treatment are always needed to improve outcomes for patients with CC. Long non-coding (lnc) RNAs are non-coding transcripts that are longer than 200 nucleotides. LncRNAs can act as oncogenes or tumor suppressor genes. Deregulation of their expression has a key role in tumor development, angiogenesis, differentiation, migration, apoptosis, and proliferation. Furthermore, detection of cancer-associated lncRNAs in body fluids, such as blood, saliva, and urine of cancer patients, is emerging as a novel method for cancer diagnosis. Although there is evidence for the potential role of lncRNAs in a number of cancers of the female genital tract, their role in CC is poorly understood. This review summarizes the current knowledge of lncRNAs in gestational CC and how this may be applied to future therapeutic strategies in the treatment of this rare cancer.en_GB
dc.language.isoenen_GB
dc.publisherMDPI AGen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectChoriocarcinomaen_GB
dc.subjectRare diseasesen_GB
dc.subjectCarcinogenesisen_GB
dc.subjectAntioncogenesen_GB
dc.subjectCancer -- Treatmenten_GB
dc.titleAn overview of the role of long non-coding RNAs in human choriocarcinomaen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.3390/ijms22126506-
dc.publication.titleInternational Journal of Molecular Sciencesen_GB
Appears in Collections:Scholarly Works - FacM&SAna

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