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DC Field | Value | Language |
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dc.contributor.author | Galea, Claire | - |
dc.contributor.author | Riva, Nicoletta | - |
dc.contributor.author | Calleja-Agius, Jean | - |
dc.date.accessioned | 2021-07-26T11:19:27Z | - |
dc.date.available | 2021-07-26T11:19:27Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Galea, C., Riva, N. & Calleja-Agius, J. (2021). Non-gynaecological applications of menstrual-derived stem cells: a systematic review. Avicenna Journal of Medical Biotechnology, | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/78667 | - |
dc.description.abstract | Menstrual-derived stem cells (MenSC) are a potential novel source of mesenchymal stem cells. There is an increased interest in investigating the therapeutic potential of MenSC due to the various advantages they exhibit, when compared to other types of stem cells. MenSC are obtained non-invasively from menstrual blood. Thus, collection of MenSC is simple, reproducible and can be carried out periodically, with minimal complications. MenSC are present in abundance, are highly proliferative, exhibit a low immunogenicity and lack ethical issues. MenSC have shown the ability to differentiate into several lineages. The therapeutic potential of MenSC in non-gynaecological applications has been investigated in wound healing, neurological, musculo-skeletal, cardiovascular, respiratory, and liver disorders, as well as in diabetes and cancer. Human clinical trials are limited. To date, therapeutic efficacy and safety have been reported in patients with Avian influenza A subtype H7N9, COVID-19, congestive heart failure, multiple sclerosis and Duchene muscular dystrophy. However, further clinical trials in humans should be conducted, to study the long-term therapeutic effects of these stem cells in various diseases and to further explore their mechanism of action. This systematic review focuses on the application of MenSC in non-gynaecological diseases. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Avicenna Research Institute | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Menstruation | en_GB |
dc.subject | Stem cells | en_GB |
dc.subject | Mesenchymal stem cells | en_GB |
dc.subject | Regenerative medicine | en_GB |
dc.subject | Cellular therapy | en_GB |
dc.title | Non-gynaecological applications of menstrual-derived stem cells: a systematic review | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.publication.title | Avicenna Journal of Medical Biotechnology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SAna Scholarly Works - FacM&SPat |
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File | Description | Size | Format | |
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Non-gynaecological_applications_of_menstrual-derived_stem_cells_a_systematic_review_2021.pdf | 855.67 kB | Adobe PDF | View/Open |
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