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dc.contributor.authorMifsud, Janet-
dc.contributor.authorSghendo, Lino-
dc.identifier.citationMifsud, J., & Sghendo, L. (2012). A novel chiral GC/MS method for the analysis of fluoxetine and norfluoxetine enantiomers in biological fluids. Journal of Pharmacy and Bioallied Sciences, 4(3), 236-245.en_GB
dc.description.abstractAIMS: A novel robust chiral gas chromatographic/mass spectrometric (GC/MS) method for the separation and measurement of fluoxetine and norfluoxetine enantiomers in urine and plasma was developed.en_GB
dc.description.abstractMATERIALS AND METHODS: The drug was extracted from the samples by a liquid-liquid technique, using chloroform, and the enantiomers were separated and measured on a chiral gas chromatographic column (HYDRODEX β-6TBDM® , 0.25 μm × 0.25 mm × 50 m). GC/MS instrumentation was used for the acquisition of data in the electron impact selective-ion monitoring mode.en_GB
dc.description.abstractRESULTS: The ions chosen were of a mass-to-charge ratio (m/z) exactly equal to 44 units, in order to measure fluoxetine enantiomers, 134 units in order to measure norfluoxetine enantiomers, and 58 units in order to measure diphenhydramine, the internal standard. The method was found to be linear and reproducible in the 50-500 ng/mL concentration range for both urine samples and plasma samples and for both fluoxetine and norfluoxetine, with correlation coefficients ranging between 0.994 and 0.997.en_GB
dc.description.abstractCONCLUSIONS: This methodology has an enormous potential for application in pharmacokinetic studies of the enantiomers of fluoxetine.en_GB
dc.publisherMedknow Publications & Media Pvt. Ltd.en_GB
dc.subjectUrine -- Analysisen_GB
dc.titleA novel chiral GC/MS method for the analysis of fluoxetine and norfluoxetine enantiomers in biological fluidsen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publication.titleJournal of Pharmacy and Bioallied Sciencesen_GB
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