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Title: The use of a non-sedating antihistamine in a hyperbaric environment
Authors: Pace, Tamsin
Mifsud, Janet
Ellul-Micallef, Roger
Fenech, A.
Cali-Corleo, R.
Keywords: Clinical pharmacology -- Malta
Hyperbaric oxygenation -- Malta
Allergy -- Malta
Asthma -- Malta
Diving -- Malta
Issue Date: 2004
Publisher: John Wiley & Sons, Inc.
Citation: Pace, T., Mifsud, J., Ellul-Micallef, R., Fenech, A., & Cali-Corleo, R. (2004). The use of a non-sedating antihistamine in a hyperbaric environment. Clinical and Experimental Pharmacology and Physiology, 31(11), A223.
Abstract: Antihistamines are associated with drowsiness and are commonly taken by divers to relieve ENT symptoms and prevent serious injury, especially where the diver has no intention to discontinue diving to allow the infection or allergy to subside. Few studies have been conducted to test whether antihistamines aggravate nitrogen narcosis, cognitive or motor functions due to any alteration in their pharmacodynamics and pharmacokinetics. Study I was a randomised double-blind placebo-controlled study, involving 50 subjects. The means of the 2 groups did not differ for diving experience, blood cell counts, liver and renal function (P< 0.05). Scales used to assess the subject mood and degree of sedation did not elucidate any statistically significant differences prior to the study. [excerpt]
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