Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/88491
Title: Modelling pharmacokinetics for antiepileptic drugs in paediatrics
Authors: Mifsud, Janet
Shabbi, H.
Soler, D.
Keywords: Pharmacokinetics -- Mathematical models
Pharmacokinetics -- Data processing
Anticonvulsants -- Mechanism of action
Epilepsy in children
Issue Date: 2006-09
Publisher: John Wiley & Sons, Inc.
Citation: Mifsud, J., Shabbi, H., & Soler, D. (2006). Modelling pharmacokinetics for antiepileptic drugs in paediatrics. European Journal of Neurology, 13(s2), 122-123.
Abstract: AIMS: Most physicians use ad hoc reasoning in the design of dosage regimens for antiepileptic drugs in children as there is still a lack of satisfactory models and software packages that will allow accurate predictions of drug levels.
METHODS: In this study, the value of a sparse data model, using AdaptĀ® software was developed for lamotrigine in paediatric patients. Plasma lamotrigine levels in 20 paediatric patients were measured. The pharmacokinetic parameters in the four groups(lamotrigine alone, valproate co-medication group, carbamazepine co-medication group, and clonazepam co-medication group) were estimated in this study using model independent pharmacokinetic equations.
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URI: https://www.um.edu.mt/library/oar/handle/123456789/88491
Appears in Collections:Scholarly Works - FacM&SCPT

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