Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/90054
Title: Possible role of circulating bone marrow mesenchymal progenitors in modulating inflammation and promoting wound repair
Authors: Grech, Laura
Ebejer, Jean Paul
Mazzitelli, Oriana
Borg, Joseph J.
Seria, Elisa
Schembri, Kevin
Keywords: Bone marrow
Mesenchymal stem cells
Wound healing
Inflammation
Issue Date: 2022
Publisher: MDPI AG
Citation: Grech, L., Ebejer, J. P., Mazzitelli, O., Schembri, K., Borg, J., & Seria, E. (2022). Possible role of circulating bone marrow mesenchymal progenitors in modulating inflammation and promoting wound repair. International Journal of Molecular Sciences, 23(1), 78.
Abstract: Circulating bone marrow mesenchymal progenitors (BMMPs) are known to be potent antigen-presenting cells that migrate to damaged tissue to secrete cytokines and growth factors. An altered or dysregulated inflammatory cascade leads to a poor healing outcome. A skin model developed in our previous study was used to observe the immuno-modulatory properties of circulating BMMP cells in inflammatory chronic wounds in a scenario of low skin perfusion. BMMPs were analysed exclusively and in conjunction with recombinant tumour necrosis factor alpha (TNF) and recombinant hepatocyte growth factor (HGF) supplementation. We analysed the expression levels of interleukin-8 (IL-8) and ecto-50-nucleotidase (CD73), together with protein levels for IL-8, stem cell factor (SCF), and fibroblast growth factor 1 (FGF-1). The successfully isolated BMMPs were positive for both hemopoietic and mesenchymal markers and showed the ability to differentiate into adipocytes, chondrocytes, and osteocytes. Significant differences were found in IL-8 and CD73 expressions and IL-8 and SCF concentrations, for all conditions studied over the three time points taken into consideration. Our data suggests that BMMPs may modulate the inflammatory response by regulating IL-8 and CD73 and influencing IL-8 and SCF protein secretions. In conclusion, we suggest that BMMPs play a role in wound repair and that their induced application might be suitable for scenarios with a low skin perfusion.
URI: https://www.um.edu.mt/library/oar/handle/123456789/90054
Appears in Collections:Scholarly Works - CenMMB
Scholarly Works - FacHScABS



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