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https://www.um.edu.mt/library/oar/handle/123456789/92942
Title: | The genomic architecture of hidradenitis suppurativa - a systematic review |
Authors: | Pace, Nikolai Paul Mintoff, Dillon Borg, Isabella |
Keywords: | Systematic reviews (Medical research) Genetics Physiology, Pathological -- Case studies Familial diseases -- Case studies Hidradenitis suppurativa |
Issue Date: | 2022 |
Publisher: | Frontiers Research Foundation |
Citation: | Pace, N. P., Mintoff, D., & Borg, I. (2022). The genomic architecture of hidradenitis suppurativa - a systematic review. Frontiers in Genetics, 13, 861241. |
Abstract: | Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin. Great strides have been made at elucidating the pathophysiology of hidradenitis suppurativa, which appears to be the product of hyperkeratinization and inflammation brought about by environmental factors and a genetic predisposition. The identification of familial hidradenitis suppurativa has sparked research aimed at identifying underlying pathogenic variants in patients who harbor them. The objective of this review is to provide a broad overview of the role of genetics in various aspects of hidradenitis suppurativa, specifically the pathophysiology, diagnosis, and clinical application. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/92942 |
Appears in Collections: | Scholarly Works - FacM&SAna |
Files in This Item:
File | Description | Size | Format | |
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The_genomic_architecture_of_hidradenitis_suppurativa.pdf | 1.11 MB | Adobe PDF | View/Open |
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