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Title: | Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds |
Authors: | Caruana Grech Perry, Mario Högen, Tobias Levin, Johannes Hillmer, Andreas Giese, Armin Vassallo, Neville |
Keywords: | Alpha-synuclein Parkinson's disease -- Pathophysiology Parkinson's disease -- Chemotherapy Polyphenols -- Physiological effect Neurobehavioral disorders -- Chemotherapy Neurobehavioral disorders -- Treatment |
Issue Date: | 2011 |
Publisher: | Elsevier |
Citation: | Caruana, M., Högen, T., Levin, J., Hillmer, A., Giese, A., & Vassallo, N. (2011). Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds. FEBS Letters, 585(8), 1113-1120. |
Abstract: | Aggregation of alpha-synuclein (αS) into oligomers is critically involved in the pathogenesis of Parkinson's disease (PD). Using confocal single-molecule fluorescence spectroscopy, we have studied the effects of 14 naturally-occurring polyphenolic compounds and black tea extract on αS oligomer formation. We found that a selected group of polyphenols exhibited potent dose-dependent inhibitory activity on αS aggregation. Moreover, they were also capable of robustly disaggregating pre-formed αS oligomers. Based upon structure-activity analysis, we propose that the key molecular scaffold most effective in inhibiting and destabilizing self-assembly by αS requires: (i) aromatic elements for binding to the αS monomer/oligomer and (ii) vicinal hydroxyl groups present on a single phenyl ring. These findings may guide the design of novel therapeutic drugs in PD. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/93246 |
Appears in Collections: | Scholarly Works - FacHScFSEH |
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Inhibition_and_disaggregation_of_a_synuclein_oligomers_by_natural_polyphenolic_compounds_2011.pdf | 822.79 kB | Adobe PDF | View/Open |
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