Analysis of two functional polymorphisms in the LRP5 gene in relation to bone mineral density and fracture risk in Maltese postmenopausal women

Formosa, Melissa Marie; Xuereb-Anastasi, Angela

Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/93248

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DC Field	Value	Language
dc.contributor.author	Formosa, Melissa Marie	-
dc.contributor.author	Xuereb-Anastasi, Angela	-
dc.date.accessioned	2022-04-08T13:49:04Z	-
dc.date.available	2022-04-08T13:49:04Z	-
dc.date.issued	2014	-
dc.identifier.citation	Formosa, M. M., & Xuereb-Anastasi, A. (2014). Analysis of two functional polymorphisms in the LRP5 gene in relation to bone mineral density and fracture risk in Maltese postmenopausal women. Osteoporosis International, 25, S422-S423.	en_GB
dc.identifier.uri	https://www.um.edu.mt/library/oar/handle/123456789/93248	-
dc.description.abstract	OBJECTIVE: The low-density lipoprotein receptor-related protein 5 (LRP5) is involved in osteoblast differentiation and bone formation, making it an important determinant of bone mass and strength. The influence of two functional missense single nucleotide polymorphisms (SNPs) A1330V (rs3736228; C>t) and V667M (rs4988321; G>a) were analysed in relation to BMD and different low-trauma fractures in Maltese postmenopausal women.	en_GB
dc.description.abstract	MATERIALS AND METHODS: 1,040 women aged 40 to 79 years were recruited and their BMD measurements were performed by dual-energy X-ray absorptiometry. Subjects without a history of a fragility fracture were subdivided in three groups: normal (n=228), osteopenic (n=266) or osteoporotic (n=280) according to their BMD results. Women with a fracture history were classified as cases (n=266). Genotyping of the A1330V polymorphism was performed by PCR followed by restriction enzyme digest, whereas real-time PCR was performed for the V667M SNP.	en_GB
dc.description.abstract	[excerpt]	en_GB
dc.language.iso	en	en_GB
dc.publisher	Springer Nature Switzerland AG	en_GB
dc.rights	info:eu-repo/semantics/restrictedAccess	en_GB
dc.subject	Genetic polymorphisms	en_GB
dc.subject	Bone density	en_GB
dc.subject	Fractures -- Risk factors	en_GB
dc.subject	Low Density Lipoprotein Receptor-Related Protein-5	en_GB
dc.subject	Osteoporosis in women -- Malta	en_GB
dc.subject	Osteoporosis -- Genetic aspects	en_GB
dc.title	Analysis of two functional polymorphisms in the LRP5 gene in relation to bone mineral density and fracture risk in Maltese postmenopausal women	en_GB
dc.type	article	en_GB
dc.rights.holder	The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.	en_GB
dc.bibliographicCitation.conferencename	World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2014)	en_GB
dc.bibliographicCitation.conferenceplace	Seville, Spain, 2-5/04/2014	en_GB
dc.description.reviewed	peer-reviewed	en_GB
dc.publication.title	Osteoporosis International	en_GB
Appears in Collections:	Scholarly Works - FacHScABS

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