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Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/93265
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dc.contributor.authorScerri, Daniel-
dc.contributor.authorSladden, André J.-
dc.contributor.authorFormosa, Melissa Marie-
dc.date.accessioned2022-04-08T15:54:29Z-
dc.date.available2022-04-08T15:54:29Z-
dc.date.issued2017-
dc.identifier.citationScerri, D., Sladden, A. J., & Formosa, M. M. (2017). Analysis of the macrophage migration inhibitory factor (MIF) gene variants with bone mineral density and fracture risk in Maltese postmenopausal women. Calcified Tissue International, 100, S94.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/93265-
dc.description.abstractOBJECTIVES: The macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that increases bone destruction in the presence of low oestrogen levels. The aim of the study was to assess the effect of two variants located at position −173 (G[C) and +656 (C[G) within the MIF gene on bone mineral density (BMD) and fracture risk in Maltese postmenopausal women. Association of the variants with biochemical variables was also analysed.en_GB
dc.description.abstractMETHODS: A case-control collection of 1045 Maltese postmenopausal women aged 41 to 79 years was used. Women who suffered a fracture were classified as cases whereas those without a fracture history were included as controls. Genotyping of MIF −173 was performed by polymerase chain reaction (PCR) and restriction enzyme digest, whereas Kompetitive Allele Specific PCR was used for the MIF +656. Genotype-phenotype associations were analysed using the Mann–Whitney test whereas odds ratios with 95% confidence intervals (CI) were computed using logistic regression analysis.en_GB
dc.description.abstract[excerpt]en_GB
dc.language.isoenen_GB
dc.publisherSpringer Nature Switzerland AGen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectMacrophage migration inhibitory factoren_GB
dc.subjectBone densityen_GB
dc.subjectFractures -- Risk factorsen_GB
dc.subjectMenopause -- Complicationsen_GB
dc.titleAnalysis of the macrophage migration inhibitory factor (MIF) gene variants with bone mineral density and fracture risk in Maltese postmenopausal womenen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.bibliographicCitation.conferencename44th European Calcified Tissue Society Congress (ECTS 2017)en_GB
dc.bibliographicCitation.conferenceplaceSalzburg, Austria, 12-16/05/2017en_GB
dc.description.reviewedpeer-revieweden_GB
dc.publication.titleCalcified Tissue Internationalen_GB
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