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dc.contributor.authorFormosa, Melissa Marie-
dc.contributor.authorXuereb-Anastasi, Angela-
dc.identifier.citationFormosa, M. M., & Xuereb-Anastasi, A. (2016). Polymorphisms in the Osteoprotegerin gene are associated with bone mineral density and fracture risk in Maltese postmenopausal women. European Journal of Human Genetics, 24, P04.072.en_GB
dc.description.abstractINTRODUCTION: Osteoprotegerin (OPG) is a decoy receptor for the Receptor activator of nuclear factor kappa-B ligand (RANKL), which blocks the interaction between RANKL and RANK thereby inhibiting osteoclastogenesis and bone resorption. Four polymorphisms within the OPG gene, and one polymorphism located 43kB upstream of OPG were analysed in relation to bone mineral density (BMD) and low-trauma fractures in Maltese postmenopausal women.en_GB
dc.description.abstractMETHODS: A case-control collection of 1045 women was used. Cases were women who suffered a fracture, whereas controls had no fracture history. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism or real-time PCR.en_GB
dc.subjectBone densityen_GB
dc.subjectFractures -- Risk factorsen_GB
dc.subjectMenopause -- Complicationsen_GB
dc.subjectGenetic polymorphismsen_GB
dc.titlePolymorphisms in the Osteoprotegerin gene are associated with bone mineral density and fracture risk in Maltese postmenopausal womenen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.bibliographicCitation.conferencename49th European Society of Human Genetics Conferenceen_GB
dc.bibliographicCitation.conferenceplaceBarcelona, Spain, 21-24/05/2016en_GB
dc.publication.titleEuropean Journal of Human Geneticsen_GB
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