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|Title:||Polymorphisms in the Osteoprotegerin gene are associated with bone mineral density and fracture risk in Maltese postmenopausal women|
|Authors:||Formosa, Melissa Marie|
Fractures -- Risk factors
Menopause -- Complications
|Citation:||Formosa, M. M., & Xuereb-Anastasi, A. (2016). Polymorphisms in the Osteoprotegerin gene are associated with bone mineral density and fracture risk in Maltese postmenopausal women. European Journal of Human Genetics, 24, P04.072.|
|Abstract:||INTRODUCTION: Osteoprotegerin (OPG) is a decoy receptor for the Receptor activator of nuclear factor kappa-B ligand (RANKL), which blocks the interaction between RANKL and RANK thereby inhibiting osteoclastogenesis and bone resorption. Four polymorphisms within the OPG gene, and one polymorphism located 43kB upstream of OPG were analysed in relation to bone mineral density (BMD) and low-trauma fractures in Maltese postmenopausal women.|
METHODS: A case-control collection of 1045 women was used. Cases were women who suffered a fracture, whereas controls had no fracture history. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism or real-time PCR.
|Appears in Collections:||Scholarly Works - FacHScABS|
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