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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Formosa, Melissa Marie | - |
| dc.contributor.author | Xuereb-Anastasi, Angela | - |
| dc.date.accessioned | 2022-04-08T16:06:21Z | - |
| dc.date.available | 2022-04-08T16:06:21Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.citation | Formosa, M. M., & Xuereb-Anastasi, A. (2015). Mutations in the LRP4 and LRP5 genes are associated with bone mineral density in Maltese postmenopausal women. IBMS BoneKEy, 13(685), P246. | en_GB |
| dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/93271 | - |
| dc.description.abstract | BACKGROUND: Osteoporosis is a multifactorial skeletal disease characterised by low bone mass leading to increased fracture risk. Members of the low-density lipoprotein receptor-related protein (LRP) gene family play a role in osteoblastogenesis through the Wingless (Wnt)/Beta-catenin pathway. LRP4 con- trols the actions of sclerostin, a Wnt inhibitor, whereas LRP5 promotes bone formation. The aim was to evaluate the effect of four non-synonymous coding polymorphisms in relation to bone mineral density (BMD) and low-trauma fractures in Mal- tese postmenopausal women. Genotyped variants were the LRP4 rs2306033 (C>T) and rs6485702 (G>A) variants, and the LRP5 rs4988321 (G>A) and rs3736228 (C>T) variants. | en_GB |
| dc.description.abstract | METHODS: Research subjects were 1045 women aged 40 to 79 years, subdivided in three BMD groups without a fracture history: normal, osteopenic or osteoporotic. Women with a fracture history were classified as cases. Genotyping was performed by polymerase chain reaction and restriction frag- ment length polymorphism, or by real-time PCR. Odds ratios were computed using logistic regression analysis adjusted for age and clinical risk factors. | en_GB |
| dc.description.abstract | [excerpt] | en_GB |
| dc.language.iso | en | en_GB |
| dc.publisher | International Bone and Mineral Society (IBMS) | en_GB |
| dc.rights | info:eu-repo/semantics/openAccess | en_GB |
| dc.subject | Osteoporosis -- Genetic aspects | en_GB |
| dc.subject | Bone density | en_GB |
| dc.subject | Osteoporosis in women -- Malta | en_GB |
| dc.title | Mutations in the LRP4 and LRP5 genes are associated with bone mineral density in Maltese postmenopausal women | en_GB |
| dc.type | article | en_GB |
| dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
| dc.bibliographicCitation.conferencename | 4th Joint Meeting of European Calcified Tissue Society and the International Bone and Mineral Society | en_GB |
| dc.bibliographicCitation.conferenceplace | Rotterdam, The Netherlands, 25-28/04/2015 | en_GB |
| dc.description.reviewed | peer-reviewed | en_GB |
| dc.publication.title | IBMS BoneKEy | en_GB |
| Appears in Collections: | Scholarly Works - FacHScABS | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ECTS2015_Mutations in the LRP4 and LRP5 genes are associated with bone mineral density in Maltese postmenopausal women.pdf | 199.38 kB | Adobe PDF | View/Open |
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