Please use this identifier to cite or link to this item:
Title: Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients
Authors: Hoogendijk, Arie J.
Wiewel, Maryse A.
Vught, Lonneke A. van
Scicluna, Brendon P.
Belkasim-Bohoudi, Hakima
Horn, Janneke
Zwinderman, Aeilko H.
Klein Klouwenberg, Peter M.C.
Cremer, Olaf L.
Bonten, Marc M.J.
Schultz, Marcus J.
Poll, Tom van der
Authors: MARS Consortium
Keywords: Biochemical markers -- Diagnostic use
Chemokines -- Immunology
Intensive care units
Outcome assessment (Medical care)
Septicemia -- Diagnosis
Issue Date: 2015
Publisher: BioMed Central Ltd.
Citation: Hoogendijk, A. J., Wiewel, M. A., van Vught, L. A., Scicluna, B. P., Belkasim-Bohoudi, H., Horn, J., ... & van der Poll, T. (2015). Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients. Critical Care, 19(1), 1-11.
Abstract: Introduction: Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limited. The primary objective of this study was to establish whether plasma fractalkine levels are elevated in sepsis and associate with outcome. The secondary objective was to determine whether fractalkine can assist in the diagnosis of infection upon ICU admission.
Methods: Fractalkine was measured in 1103 consecutive sepsis patients (including 271 patients with community-acquired pneumonia (CAP)) upon ICU admission and at days 2 and 4 thereafter; in 73 ICU patients treated for suspected CAP in whom this diagnosis was refuted in retrospect; and in 5 healthy humans intravenously injected with endotoxin.
Results: Compared to healthy volunteers, sepsis patients had strongly elevated fractalkine levels. Fractalkine levels increased with the number of organs failing, were higher in patients presenting with shock, but did not vary by site of infection. Non-survivors had sustained elevated fractalkine levels when compared to survivors. Fractalkine was equally elevated in CAP patients and patients treated for CAP but in whom the diagnosis was retrospectively refuted. Fractalkine release induced by intravenous endotoxin followed highly similar kinetics as the endothelial cell marker E-selectin.
Conclusions: Plasma fractalkine is an endothelial cell derived biomarker that, while not specific for infection, correlates with disease severity in sepsis patients admitted to the ICU.
Appears in Collections:Scholarly Works - FacHScABS

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.